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MetaCyc Reaction: 2.4.1.109

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.4.1.109

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: dolichyl-phosphate-mannose--protein mannosyltransferase

Enzyme Commission Synonyms: dolichol phosphomannose-protein mannosyltransferase, protein O-D-mannosyltransferase

Taxonomic Range: Fungi , Bacteria , Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): -95.1897 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain α-dihydropolyprenyl derivatives, larger than C35.

Citations: [Babczinski80, Palamarczyk80]

Relationship Links: BRENDA:EC:2.4.1.109 , ENZYME:EC:2.4.1.109 , IUBMB-ExplorEnz:EC:2.4.1.109 , UniProt:RELATED-TO:P31382 , UniProt:RELATED-TO:P33775 , UniProt:RELATED-TO:P46971 , UniProt:RELATED-TO:P47190


References

Babczinski80: Babczinski P, Haselbeck A, Tanner W (1980). "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme." Eur J Biochem 105(3);509-15. PMID: 6989607

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Palamarczyk80: Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W (1980). "Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives." Eur J Biochem 105(3);517-23. PMID: 6445267


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Aug 28, 2015, BIOCYC14A.