MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Saccharomyces cerevisiae : UDP-glucose:dolichyl-phosphate glucosyltransferase Inferred from experiment : ALG5

In Pathway: protein N-glycosylation (eukaryotic, high mannose)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: dolichyl-phosphate β-glucosyltransferase

Enzyme Commission Synonyms: polyprenyl phosphate:UDP-D-glucose glucosyltransferase, UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol phosphate glucosyltransferase, UDP-glucose:dolicholphosphoryl glucosyltransferase, UDP-glucose:dolichyl monophosphate glucosyltransferase, UDP-glucose:dolichyl phosphate glucosyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.62390137 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Solanesyl phosphate and ficaprenyl phosphate can act as acceptors, but more slowly.

Citations: [Behrens70, Herscovics77, Villemez79]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01005 , Rhea:15401

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P40350 , UniProt:RELATED-TO:Q9UUT0 , UniProt:RELATED-TO:Q9Y673


Behrens70: Behrens NH, Leloir LF (1970). "Dolichol monophosphate glucose: an intermediate in glucose transfer in liver." Proc Natl Acad Sci U S A 66(1);153-9. PMID: 5273893

Herscovics77: Herscovics A, Bugge B, Jeanloz RW (1977). "Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose." J Biol Chem 252(7);2271-7. PMID: 849929

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Villemez79: Villemez CL, Carlo PL (1979). "Properties of a soluble polyprenyl phosphate: UDP-D-glucose glucosyltransferase." J Biol Chem 254(11);4814-9. PMID: 438216

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 13, 2015, biocyc13.