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MetaCyc Reaction: 2.4.1.142

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.4.1.142

Enzymes and Genes:

Saccharomyces cerevisiae: Dol-PP-GlcNAc2:Man transferaseInferred from experiment: ALG1

In Pathway: protein N-glycosylation (eukaryotic, high mannose)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: chitobiosyldiphosphodolichol β-mannosyltransferase

Enzyme Commission Synonyms: guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase, GDP-mannose-dolichol diphosphochitobiose mannosyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 6.897827Inferred by computational analysis [Latendresse13]

Citations: [Takahashi00, Sharma82]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04502

Relationship Links: BRENDA:EC:2.4.1.142, ENZYME:EC:2.4.1.142, IUBMB-ExplorEnz:EC:2.4.1.142


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sharma82: Sharma CB, Lehle L, Tanner W (1982). "Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast." Eur J Biochem 126(2);319-25. PMID: 6215245

Takahashi00: Takahashi T, Honda R, Nishikawa Y (2000). "Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1." Glycobiology 10(3);321-7. PMID: 10704531


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Feb 9, 2016, biocyc14.