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MetaCyc Reaction: 2.4.1.153

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.4.1.153

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Instance reaction:
ω-saturated C55 dolichol phosphate + UDP-N-acetyl-α-D-glucosamine → N-acetyl-α-D-glucosaminyl-(C55 ω-saturated dolichyl phosphate) + UDP (2.4.1.153)

Enzyme Commission Primary Name: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminyltransferase

Enzyme Commission Synonyms: uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase, dolichyl phosphate acetylglucosaminyltransferase, dolichyl phosphate N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.6240845Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, initiates N-linked glycosylation in that organism. The enzyme differs from the eukaryotic enzyme, which leaves one additional phosphate group on the dolichyl product (cf. EC 2.7.8.15, UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase).

Citations: [Larkin13]

Unification Links: KEGG:R01008, Rhea:14693

Relationship Links: BRENDA:EC:2.4.1.153, ENZYME:EC:2.4.1.153, IUBMB-ExplorEnz:EC:2.4.1.153


References

Larkin13: Larkin A, Chang MM, Whitworth GE, Imperiali B (2013). "Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis." Nat Chem Biol 9(6);367-73. PMID: 23624439

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc11.