MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Instance reaction:
UDP-α-D-galactose + glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate → galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate + UDP + H+ (

Enzyme Commission Primary Name: lipopolysaccharide 3-α-galactosyltransferase

Enzyme Commission Synonyms: UDP-galactose:lipopolysaccharide α,3-galactosyltransferase, UDP-galactose:polysaccharide galactosyltransferase, uridine diphosphate galactose:lipopolysaccharide α-3-galactosyltransferase, uridine diphosphogalactose-lipopolysaccharide α,3-galactosyltransferase, UDP-galactose:lipopolysaccharide 3-α-D-galactosyltransferase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 502.26935 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Transfers α-D-galactosyl residues to D-glucose in the partially completed core of lipopolysaccharide [cf. EC (lipopolysaccharide N-acetylglucosaminyltransferase), EC (lipopolysaccharide glucosyltransferase I) and EC (lipopolysaccharide glucosyltransferase II)].

Citations: [Endo69, Wollin83]

Unification Links: KEGG:R01997

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P27128

Revised 05-Sep-2012 by Caspi R , SRI International


Endo69: Endo A, Rothfield L (1969). "Studies of a phospholipid-requiring bacterial enzyme. I. Purification and properties of uridine diphosphate galactose: lipopolysaccharide alpha-3-galactosyl transferase." Biochemistry 8(9);3500-7. PMID: 4898284

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wollin83: Wollin R, Creeger ES, Rothfield LI, Stocker BA, Lindberg AA (1983). "Salmonella typhimurium mutants defective in UDP-D-galactose:lipopolysaccharide alpha 1,6-D-galactosyltransferase. Structural, immunochemical, and enzymologic studies of rfaB mutants." J Biol Chem 258(6);3769-74. PMID: 6403519

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Oct 8, 2015, biocyc13.