Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.1.153

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.153

Enzymes and Genes:
phosphatidylinositol 3-kinase class IA p110δ/p85β Inferred from experiment : PIK3R2 , PIK3CD ( Homo sapiens )
phosphatidylinositol 3-kinase class IA p110β/p85γ Inferred from experiment : PIK3R3 , PIK3CB ( Homo sapiens )
phosphatidylinositol 3-kinase class IA p110α/p85α Inferred from experiment : PIK3R1 , PIK3CA ( Homo sapiens )
phosphatidylinositol 3-kinase, class IB, p110γ/p101 Inferred from experiment : PIK3R5 , PIK3CG ( Homo sapiens )
phosphatidylinositol 3-kinase, class IB, p110γ/p87 Inferred from experiment : PIK3R6 , PIK3CG ( Homo sapiens )

In Pathway: 3-phosphoinositide biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphatidylinositol-4,5-bisphosphate 3-kinase

Enzyme Commission Synonyms: type I phosphoinositide 3-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.785767 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P.

Citations: [Vanhaesebroeck01]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04545 , Rhea:21292

Relationship Links: BRENDA:EC:2.7.1.153 , ENZYME:EC:2.7.1.153 , IUBMB-ExplorEnz:EC:2.7.1.153


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Vanhaesebroeck01: Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids." Annu Rev Biochem 70;535-602. PMID: 11395417


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13B.