MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Homo sapiens: phosphatidylinositol 3-kinase, class IB, p110γ/p87Inferred from experiment: PIK3R6, PIK3CG
phosphatidylinositol 3-kinase, class IB, p110γ/p101Inferred from experiment: PIK3R5, PIK3CG
phosphatidylinositol 3-kinase class IA p110α/p85αInferred from experiment: PIK3R1, PIK3CA
phosphatidylinositol 3-kinase class IA p110β/p85γInferred from experiment: PIK3R3, PIK3CB
phosphatidylinositol 3-kinase class IA p110δ/p85βInferred from experiment: PIK3R2, PIK3CD

In Pathway: 3-phosphoinositide biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphatidylinositol-4,5-bisphosphate 3-kinase

Enzyme Commission Synonyms: type I phosphoinositide 3-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.785767Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P.

Citations: [Vanhaesebroeck01]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04545, Rhea:21292

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Vanhaesebroeck01: Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids." Annu Rev Biochem 70;535-602. PMID: 11395417

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Dec 1, 2015, biocyc11.