MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Homo sapiens : phosphatidylinositol 3-kinase, class IB, p110γ/p87 Inferred from experiment : PIK3R6 , PIK3CG
phosphatidylinositol 3-kinase, class IB, p110γ/p101 Inferred from experiment : PIK3R5 , PIK3CG
phosphatidylinositol 3-kinase class IA p110α/p85α Inferred from experiment : PIK3R1 , PIK3CA
phosphatidylinositol 3-kinase class IA p110β/p85γ Inferred from experiment : PIK3R3 , PIK3CB
phosphatidylinositol 3-kinase class IA p110δ/p85β Inferred from experiment : PIK3R2 , PIK3CD

In Pathway: 3-phosphoinositide biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphatidylinositol-4,5-bisphosphate 3-kinase

Enzyme Commission Synonyms: type I phosphoinositide 3-kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.785767 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P.

Citations: [Vanhaesebroeck01]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R04545 , Rhea:21292

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Vanhaesebroeck01: Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids." Annu Rev Biochem 70;535-602. PMID: 11395417

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc13.