|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Homo sapiens:||phosphatidylinositol 3-kinase, class IB, p110γ/p87: PIK3R6, PIK3CG|
phosphatidylinositol 3-kinase, class IB, p110γ/p101: PIK3R5, PIK3CG
phosphatidylinositol 3-kinase class IA p110α/p85α: PIK3R1, PIK3CA
phosphatidylinositol 3-kinase class IA p110β/p85γ: PIK3R3, PIK3CB
phosphatidylinositol 3-kinase class IA p110δ/p85β: PIK3R2, PIK3CD
In Pathway: 3-phosphoinositide biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: phosphatidylinositol-4,5-bisphosphate 3-kinase
Enzyme Commission Synonyms: type I phosphoinositide 3-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -10.785767 [Latendresse13]
Enzyme Commission Summary:
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P.
Vanhaesebroeck01: Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids." Annu Rev Biochem 70;535-602. PMID: 11395417
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