|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
phosphatidylinositol 3-kinase class IA p110δ/p85β : PIK3R2 , PIK3CD ( Homo sapiens )
phosphatidylinositol 3-kinase class IA p110β/p85γ : PIK3R3 , PIK3CB ( Homo sapiens )
phosphatidylinositol 3-kinase class IA p110α/p85α : PIK3R1 , PIK3CA ( Homo sapiens )
phosphatidylinositol 3-kinase, class IB, p110γ/p101 : PIK3R5 , PIK3CG ( Homo sapiens )
phosphatidylinositol 3-kinase, class IB, p110γ/p87 : PIK3R6 , PIK3CG ( Homo sapiens )
In Pathway: 3-phosphoinositide biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: phosphatidylinositol-4,5-bisphosphate 3-kinase
Enzyme Commission Synonyms: type I phosphoinositide 3-kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -10.785767 [Latendresse13]
Enzyme Commission Summary:
This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P.
Vanhaesebroeck01: Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD (2001). "Synthesis and function of 3-phosphorylated inositol lipids." Annu Rev Biochem 70;535-602. PMID: 11395417
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