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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.1.69

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Group Translocation Phosphenolpyruvate (PEP)-Dependent Transport
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Conversion Type Simple Reactions Transport Reactions Group Translocation Phosphenolpyruvate (PEP)-Dependent Transport
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.7.1.69

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: protein-Nπ-phosphohistidine—sugar phosphotransferase

Enzyme Commission Synonyms: glucose permease, PTS permease, phosphotransferase, phosphohistidinoprotein-hexose, enzyme IIl4ac, gene glC proteins, gene bglC RNA formation factors, PEP-dependent phosphotransferase enzyme II, PEP-sugar phosphotransferase enzyme II, phosphoenolpyruvate-sugar phosphotransferase enzyme II, phosphohistidinoprotein-hexose phosphotransferase, phosphohistidinoprotein-hexose phosphoribosyltransferase, phosphoprotein factor-hexose phosophotransferase, protein, specific or class, gene bglC, ribonucleic acid formation factor, gene glC, sucrose phosphotransferase system II, protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase, protein-Npi-phosphohistidine:sugar Npi-phosphotransferase

Enzyme Commission Summary:
Enzyme II of the phosphotransferase system. Comprises a group of related enzymes. The protein substrate is a phosphocarrier protein of low molecular mass (9.5 kDa). The protein is phosphorylated in a reaction catalysed by EC 2.7.3.9, phosphoenolpyruvate—protein phosphotransferase and this acts as the phosphate donor for the above reaction.

The enzyme translocates the sugar it phosphorylates into bacteria. Aldohexoses, and their glycosides and alditols, are phosphorylated on O-6, whereas fructose and sorbose are phosphorylated on O-1. Glycerone and disaccharides are also substrates.

Citations: [Kornberg76, Postma76]

Unification Links: KEGG:R03076

Relationship Links: BRENDA:EC:2.7.1.69 , ENZYME:EC:2.7.1.69 , IUBMB-ExplorEnz:EC:2.7.1.69 , UniProt:RELATED-TO:O34521 , UniProt:RELATED-TO:O51000 , UniProt:RELATED-TO:O51590 , UniProt:RELATED-TO:P00550 , UniProt:RELATED-TO:P05306 , UniProt:RELATED-TO:P05706 , UniProt:RELATED-TO:P08470 , UniProt:RELATED-TO:P08722 , UniProt:RELATED-TO:P09323 , UniProt:RELATED-TO:P0A0D6 , UniProt:RELATED-TO:P0A0E0 , UniProt:RELATED-TO:P0A283 , UniProt:RELATED-TO:P11162 , UniProt:RELATED-TO:P11502 , UniProt:RELATED-TO:P12655 , UniProt:RELATED-TO:P17162 , UniProt:RELATED-TO:P17334 , UniProt:RELATED-TO:P17876 , UniProt:RELATED-TO:P19642 , UniProt:RELATED-TO:P20166 , UniProt:RELATED-TO:P20966 , UniProt:RELATED-TO:P23355 , UniProt:RELATED-TO:P23387 , UniProt:RELATED-TO:P23531 , UniProt:RELATED-TO:P24241 , UniProt:RELATED-TO:P24400 , UniProt:RELATED-TO:P26381 , UniProt:RELATED-TO:P26382 , UniProt:RELATED-TO:P26426 , UniProt:RELATED-TO:P27219 , UniProt:RELATED-TO:P27547 , UniProt:RELATED-TO:P28008 , UniProt:RELATED-TO:P37082 , UniProt:RELATED-TO:P37083 , UniProt:RELATED-TO:P37439 , UniProt:RELATED-TO:P39794 , UniProt:RELATED-TO:P41029 , UniProt:RELATED-TO:P43470 , UniProt:RELATED-TO:P44714 , UniProt:RELATED-TO:P45338 , UniProt:RELATED-TO:P45597 , UniProt:RELATED-TO:P45604 , UniProt:RELATED-TO:P50829 , UniProt:RELATED-TO:P54745 , UniProt:RELATED-TO:P56579 , UniProt:RELATED-TO:P56580 , UniProt:RELATED-TO:P69783 , UniProt:RELATED-TO:P69786 , UniProt:RELATED-TO:P69791 , UniProt:RELATED-TO:P69795 , UniProt:RELATED-TO:P69797 , UniProt:RELATED-TO:P69801 , UniProt:RELATED-TO:P69805 , UniProt:RELATED-TO:P69811 , UniProt:RELATED-TO:P69824 , UniProt:RELATED-TO:P69826 , UniProt:RELATED-TO:P69829 , UniProt:RELATED-TO:P74938 , UniProt:RELATED-TO:Q9JWF9 , UniProt:RELATED-TO:Q9X674 , UniProt:RELATED-TO:Q9X675 , UniProt:RELATED-TO:Q9X676 , UniProt:RELATED-TO:Q02420 , UniProt:RELATED-TO:Q44840 , UniProt:RELATED-TO:Q48978 , UniProt:RELATED-TO:Q48998 , UniProt:RELATED-TO:Q49019 , UniProt:RELATED-TO:Q49029 , UniProt:RELATED-TO:Q49037 , UniProt:RELATED-TO:Q49057 , UniProt:RELATED-TO:Q49076 , UniProt:RELATED-TO:Q49089 , UniProt:RELATED-TO:Q53922 , UniProt:RELATED-TO:Q57071


References

Kornberg76: Kornberg HL, Riordan C (1976). "Uptake of galactose into Escherichia coli by facilitated diffusion." J Gen Microbiol 94(1);75-89. PMID: 778334

Postma76: Postma, P.W., Roseman, S. (1976). "The bacterial phosphoenolpyruvate: sugar phosphotransferase system." Biochim Biophys Acta 457(3-4);213-57. PMID: 187249


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14A.