|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: gentamicin 2′′-nucleotidyltransferase
Enzyme Commission Synonyms: gentamicin 2''-adenylyltransferase, aminoglycoside adenylyltransferase, gentamycin 2''-nucleotidyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -106.438416 [Latendresse13]
Enzyme Commission Summary:
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
Unification Links: KEGG:R02432
Angelatou82: Angelatou F, Litsas SB, Kontomichalou P (1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa." J Antibiot (Tokyo) 35(2);235-44. PMID: 6281224
Naganawa71: Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H (1971). "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B." J Antibiot (Tokyo) 24(12);913-4. PMID: 4946513
Yagisawa71: Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T (1971). "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor." J Antibiot (Tokyo) 24(12);911-2. PMID: 4946512
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