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MetaCyc Reaction: 2.7.7.46

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.7.7.46

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: gentamicin 2′′-nucleotidyltransferase

Enzyme Commission Synonyms: gentamicin 2''-adenylyltransferase, aminoglycoside adenylyltransferase, gentamycin 2''-nucleotidyltransferase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -106.438416Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.

Citations: [Yagisawa71, Naganawa71, Angelatou82]

Unification Links: KEGG:R02432

Relationship Links: BRENDA:EC:2.7.7.46, ENZYME:EC:2.7.7.46, IUBMB-ExplorEnz:EC:2.7.7.46, UniProt:RELATED-TO:P0AE05, UniProt:RELATED-TO:P29806, UniProt:RELATED-TO:Q08771


References

Angelatou82: Angelatou F, Litsas SB, Kontomichalou P (1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa." J Antibiot (Tokyo) 35(2);235-44. PMID: 6281224

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Naganawa71: Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H (1971). "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B." J Antibiot (Tokyo) 24(12);913-4. PMID: 4946513

Yagisawa71: Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T (1971). "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor." J Antibiot (Tokyo) 24(12);911-2. PMID: 4946512


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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