Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.7.46

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.7.46

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: gentamicin 2′′-nucleotidyltransferase

Enzyme Commission Synonyms: gentamicin 2''-adenylyltransferase, aminoglycoside adenylyltransferase, gentamycin 2''-nucleotidyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -106.438416 Inferred by computational analysis [Latendresse, 2013]

Enzyme Commission Summary:
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.

Citations: [Yagisawa71, Naganawa71, Angelatou82]

Unification Links: KEGG:R02432

Relationship Links: BRENDA:EC:2.7.7.46 , ENZYME:EC:2.7.7.46 , IUBMB-ExplorEnz:EC:2.7.7.46 , UniProt:RELATED-TO:P0AE05 , UniProt:RELATED-TO:P29806 , UniProt:RELATED-TO:Q08771


References

Angelatou82: Angelatou F, Litsas SB, Kontomichalou P (1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa." J Antibiot (Tokyo) 35(2);235-44. PMID: 6281224

Latendresse, 2013: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Naganawa71: Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H (1971). "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B." J Antibiot (Tokyo) 24(12);913-4. PMID: 4946513

Yagisawa71: Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T (1971). "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor." J Antibiot (Tokyo) 24(12);911-2. PMID: 4946512


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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