Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.7.61

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.7.7.61

Enzymes and Genes:
apo-citrate lyase phosphoribosyl-dephospho-CoA transferase Inferred from experiment : citX ( Escherichia coli K-12 substr. MG1655 )

In Pathway: citrate lyase activation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: The right side is missing: H: 1

Enzyme Commission Primary Name: citrate lyase holo-[acyl-carrier protein] synthase

Enzyme Commission Synonyms: 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase, 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase, CitX, holo-ACP synthase (ambiguous), 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase, 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase, 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase adenylyltransferase, holo-citrate lyase synthase (incorrect)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -526.61804 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The γ-subunit of EC 4.1.3.6, citrate (pro-3S)-lyase, serves as an acyl-carrier protein (ACP) and contains the prosthetic group 2'-(5''-triphospho-α-D-ribosyl)-3'-dephospho-CoA [Schneider00a, Schneider02]. Synthesis and attachment of the prosthetic group requires the concerted action of this enzyme and EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase [Schneider00a]. In the enzyme from E. coli, the prosthetic group is attached to serine-14 of the ACP via a phosphodiester bond.

Citations: [Schneider00]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.7.61 , ENZYME:EC:2.7.7.61 , IUBMB-ExplorEnz:EC:2.7.7.61


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Schneider00: Schneider K, Dimroth P, Bott M (2000). "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group." FEBS Lett 2000;483(2-3);165-8. PMID: 11042274

Schneider00a: Schneider K, Dimroth P, Bott M (2000). "Biosynthesis of the prosthetic group of citrate lyase." Biochemistry 2000;39(31);9438-50. PMID: 10924139

Schneider02: Schneider K, Kastner CN, Meyer M, Wessel M, Dimroth P, Bott M (2002). "Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group." J Bacteriol 2002;184(9);2439-46. PMID: 11948157


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14A.