Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.14.13.23

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.23

Enzymes and Genes:
3-hydroxybenzoate 4-hydroxylase Inferred from experiment ( Pseudomonas alcaligenes NCIMB 9867 )

In Pathway: m-cresol degradation

Supersedes EC number: 1.14.99.13

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxybenzoate 4-monooxygenase

Enzyme Commission Synonyms: 3-hydroxybenzoate 4-hydroxylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -91.90051 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.

Citations: [Michalover73, Premkumar69, Nakazawa78]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01628 , Rhea:11480

Relationship Links: BRENDA:EC:1.14.13.23 , ENZYME:EC:1.14.13.23 , IUBMB-ExplorEnz:EC:1.14.13.23


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Michalover73: Michalover JL, Ribbons DW, Hughes H (1973). "3-Hydroxybenzoate 4-hydroxylase from Pseudomonas testosteroni." Biochem Biophys Res Commun 55(3);888-96. PMID: 4148586

Nakazawa78: Nakazawa T, Hayashi E (1978). "Phthalate and 4-hydroxyphthalate metabolism in Pseudomonas testosteroni: purification and properties of 4,5-dihydroxyphthalate decarboxylase." Appl Environ Microbiol 1978;36(2);264-9. PMID: 29563

Premkumar69: Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS (1969). "m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger." Can J Biochem 47(8);825-7. PMID: 4390252


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc13.