Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.14.13.23

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.23

Enzymes and Genes:
3-hydroxybenzoate 4-hydroxylase Inferred from experiment ( Pseudomonas alcaligenes NCIMB 9867 )

In Pathway: m-cresol degradation

Supersedes EC number: 1.14.99.13

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxybenzoate 4-monooxygenase

Enzyme Commission Synonyms: 3-hydroxybenzoate 4-hydroxylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -91.90051 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.

Citations: [Michalover73, Premkumar69, Nakazawa78]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01628 , Rhea:11480

Relationship Links: BRENDA:EC:1.14.13.23 , ENZYME:EC:1.14.13.23 , IUBMB-ExplorEnz:EC:1.14.13.23


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Michalover73: Michalover JL, Ribbons DW, Hughes H (1973). "3-Hydroxybenzoate 4-hydroxylase from Pseudomonas testosteroni." Biochem Biophys Res Commun 55(3);888-96. PMID: 4148586

Nakazawa78: Nakazawa T, Hayashi E (1978). "Phthalate and 4-hydroxyphthalate metabolism in Pseudomonas testosteroni: purification and properties of 4,5-dihydroxyphthalate decarboxylase." Appl Environ Microbiol 1978;36(2);264-9. PMID: 29563

Premkumar69: Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS (1969). "m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger." Can J Biochem 47(8);825-7. PMID: 4390252


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14A.