MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Pseudomonas alcaligenes NCIMB 9867: 3-hydroxybenzoate 4-hydroxylaseInferred from experiment

In Pathway: m-cresol degradation

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxybenzoate 4-monooxygenase

Enzyme Commission Synonyms: 3-hydroxybenzoate 4-hydroxylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -91.90051Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Acts also on a number of analogues of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.

Citations: [Michalover73, Premkumar69 , Nakazawa78]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01628, Rhea:11480

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Michalover73: Michalover JL, Ribbons DW, Hughes H (1973). "3-Hydroxybenzoate 4-hydroxylase from Pseudomonas testosteroni." Biochem Biophys Res Commun 55(3);888-96. PMID: 4148586

Nakazawa78: Nakazawa T, Hayashi E (1978). "Phthalate and 4-hydroxyphthalate metabolism in Pseudomonas testosteroni: purification and properties of 4,5-dihydroxyphthalate decarboxylase." Appl Environ Microbiol 1978;36(2);264-9. PMID: 29563

Premkumar69: Premkumar R, Rao PV, Sreeleela NS, Vaidyanathan CS (1969). "m-Hydroxybenzoic acid 4-hydroxylase from Aspergillus niger." Can J Biochem 47(8);825-7. PMID: 4390252

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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