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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: acylhydrolaseInferred from experiment: DSEL
Saccharomyces cerevisiae: monoacylglycerol lipaseInferred from experiment: YJU3

In Pathway: triacylglycerol degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
1-oleoyl-sn-glycerol + H2O → glycerol + oleate + H+ (

Enzyme Commission Primary Name: acylglycerol lipase

Enzyme Commission Synonyms: monoacylglycerol lipase, monoacylglycerolipase, monoglyceride lipase, monoglyceride hydrolase, fatty acyl monoester lipase, monoacylglycerol hydrolase, monoglyceridyllipase, monoglyceridase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 66.41072Inferred by computational analysis [Latendresse13]

Citations: [Mentlein80, Pope66]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a 1-monoglyceride + H2O → a fatty acid + glycerol + H+] (
i14: 1-oleoyl-sn-glycerol + H2O → glycerol + oleate + H+ (

Instance reactions of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (
i11: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (

i12: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O → 1-18:2-lysophosphatidylcholine + palmitate + H+ (

Unification Links: KEGG:R01351, Rhea:34019

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mentlein80: Mentlein R, Heiland S, Heymann E (1980). "Simultaneous purification and comparative characterization of six serine hydrolases from rat liver microsomes." Arch Biochem Biophys 200(2);547-59. PMID: 6776896

Pope66: Pope JL, McPherson JC, Tidwell HC (1966). "A study of a monoglyceride-hydrolyzing enzyme of intestinal mucosa." J Biol Chem 241(10);2306-10. PMID: 5916497

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Feb 12, 2016, biocyc13.