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MetaCyc Reaction: 3.1.1.23

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.23

Enzymes and Genes:
monoacylglycerol lipase Inferred from experiment : YJU3 ( Saccharomyces cerevisiae )
acylhydrolase Inferred from experiment : DSEL ( Arabidopsis thaliana col )

In Pathway: triacylglycerol degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
1-oleoylglycerol + H2O → glycerol + oleate + H+ (3.1.1.23)

Enzyme Commission Primary Name: acylglycerol lipase

Enzyme Commission Synonyms: monoacylglycerol lipase, monoacylglycerolipase, monoglyceride lipase, monoglyceride hydrolase, fatty acyl monoester lipase, monoacylglycerol hydrolase, monoglyceridyllipase, monoglyceridase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 66.41072 Inferred by computational analysis [Latendresse13]

Citations: [Mentlein80, Pope66]

Gene-Reaction Schematic: ?

Instance reactions of [a phosphatidylcholine + H2O → a 2-lyso-phosphatidylcholine + a fatty acid + H+] (3.1.1.4):
i4: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O → 1-18:2-lysophosphatidylcholine + palmitate + H+ (3.1.1.32)

i5: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (3.1.1.4)

Instance reaction of [a 1-monoglyceride + H2O → a fatty acid + glycerol + H+] (3.1.1.23):
i7: 1-oleoylglycerol + H2O → glycerol + oleate + H+ (3.1.1.23)

Unification Links: KEGG:R01351 , Rhea:34019

Relationship Links: BRENDA:EC:3.1.1.23 , ENZYME:EC:3.1.1.23 , IUBMB-ExplorEnz:EC:3.1.1.23


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mentlein80: Mentlein R, Heiland S, Heymann E (1980). "Simultaneous purification and comparative characterization of six serine hydrolases from rat liver microsomes." Arch Biochem Biophys 200(2);547-59. PMID: 6776896

Pope66: Pope JL, McPherson JC, Tidwell HC (1966). "A study of a monoglyceride-hydrolyzing enzyme of intestinal mucosa." J Biol Chem 241(10);2306-10. PMID: 5916497


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Jan 31, 2015, BIOCYC14A.