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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Aspergillus niger: feruloyl esterase AInferred from experiment: faeA
Ruminiclostridium thermocellum ATCC 27405: endo-1,4-β-xylanase XynZInferred from experiment: xynZ
endo-1,4-β-xylanase XynYInferred from experiment: xynY

In Pathway: cellulose and hemicellulose degradation (cellulolosome)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: feruloyl esterase

Enzyme Commission Synonyms: ferulic acid esterase, hydroxycinnamoyl esterase, hemicellulase accessory enzymes, FAE-III, cinnamoyl ester hydrolase, FAEA, cinnAE, FAE-I, FAE-II

Standard Gibbs Free Energy (ΔrG in kcal/mol): 74.00185Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Catalyzes the hydrolysis of the 4-hydroxy-3-methoxycinnamoyl (feruloyl) group from an esterified sugar, which is usually arabinose in 'natural' substrates. p-nitrophenol acetate and methyl ferulate are poorer substrates. All microbial ferulate esterases are secreted into the culture medium. They are sometimes called hemicellulase accessory enzymes, since they help xylanases and pectinases to break down plant cell wall hemicellulose.

Citations: [deVries97, Kroon96, Faulds91]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R07292

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


deVries97: de Vries RP, Michelsen B, Poulsen CH, Kroon PA, van den Heuvel RH, Faulds CB, Williamson G, van den Hombergh JP, Visser J (1997). "The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides." Appl Environ Microbiol 63(12);4638-44. PMID: 9406381

Faulds91: Faulds CB, Williamson G (1991). "The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes." J Gen Microbiol 137(10);2339-45. PMID: 1663152

Kroon96: Kroon PA, Faulds CB, Williamson G (1996). "Purification and characterization of a novel esterase induced by growth of Aspergillus niger on sugar-beet pulp." Biotechnol Appl Biochem 23 ( Pt 3);255-62. PMID: 8679110

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Apr 29, 2016, biocyc13.