|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
acyl-coA hydrolase (long chain) : CESdD1 ( Canis lupus familiaris )
thioesterase II : tesB ( Escherichia coli K-12 substr. MG1655 )
acyl-CoA thioesterase : yciA ( Escherichia coli K-12 substr. MG1655 )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
propanoyl-CoA + H2O → propanoate + coenzyme A + H+ (22.214.171.124)
Direct generic reaction:
an acyl-CoA + H2O → a carboxylate + coenzyme A + H+ (126.96.36.199)
Enzyme Commission Primary Name: ADP-dependent short-chain-acyl-CoA hydrolase
Enzyme Commission Synonyms: short-chain acyl coenzyme A hydrolase, propionyl coenzyme A hydrolase, propionyl-CoA hydrolase, propionyl-CoA thioesterase, short-chain acyl-CoA hydrolase, short-chain acyl-CoA thioesterase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 312.0276 [Latendresse13]
Enzyme Commission Summary:
Requires ADP; inhibited by NADH. Maximum activity is shown with propanoyl-CoA.
Unification Links: KEGG:R00383
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