|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: mannosyl-glycoprotein endo-β-N-acetylglucosaminidase
Enzyme Commission Synonyms: N,N'-diacetylchitobiosyl β-N-acetylglucosaminidase, endo-β-N-acetylglucosaminidase, mannosyl-glycoprotein endo-β-N-acetylglucosamidase, di-N-acetylchitobiosyl β-N-acetylglucosaminidase, endo-β-acetylglucosaminidase, endo-β-(1->4)-N-acetylglucosaminidase, mannosyl-glycoprotein 1,4-N-acetamidodeoxy-β-D-glycohydrolase, endoglycosidase S, endo-N-acetyl-β-D-glucosaminidase, endo-N-acetyl-β-glucosaminidase, endo-β-N-acetylglucosaminidase D, endo-β-N-acetylglucosaminidase F, endo-β-N-acetylglucosaminidase H, endo-β-N-acetylglucosaminidase L, glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-β-glucosaminohydrolase, endoglycosidase H
Enzyme Commission Summary:
This enzyme catalyzes endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn- structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.
A group of related enzymes.
Relationship Links: BRENDA:EC:220.127.116.11 , ENZYME:EC:18.104.22.168 , IUBMB-ExplorEnz:EC:22.214.171.124 , UniProt:RELATED-TO:P04067 , UniProt:RELATED-TO:P13670 , UniProt:RELATED-TO:P49610 , UniProt:RELATED-TO:Q9CFI4 , UniProt:RELATED-TO:Q9R5G5
Koide74: Koide N, Muramatsu T (1974). "Endo-beta-N-acetylglucosaminidase acting on carbohydrate moieties of glycoproteins. Purification and properties of the enzyme from Diplococcus pneumoniae." J Biol Chem 249(15);4897-904. PMID: 4152561
Pierce80: Pierce RJ, Spik G, Montreuil J (1980). "Demonstration and cytosolic location of an endo-N-acetyl-beta-D-glucosaminidase activity towards an asialo-N-acetyl-lactosaminic-type substrate in rat liver." Biochem J 185(1);261-4. PMID: 7378051
Tai75: Tai T, Yamashita K, Ogata-Arakawa M, Koide N, Muramatsu T, Iwashita S, Inoue Y, Kobata A (1975). "Structural studies of two ovalbumin glycopeptides in relation to the endo-beta-N-acetylglucosaminidase specificity." J Biol Chem 250(21);8569-75. PMID: 389
Tarentino74: Tarentino AL, Plummer TH, Maley F (1974). "The release of intact oligosaccharides from specific glycoproteins by endo-beta-N-acetylglucosaminidase H." J Biol Chem 249(3);818-24. PMID: 4204553
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493