MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: aminopeptidase S

Enzyme Commission Synonyms: Mername-AA022 peptidase, SGAP, aminopeptidase (Streptomyces griseus), Streptomyces griseus aminopeptidase, S. griseus AP, double-zinc aminopeptidase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -48.12524Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Activated by Ca(2+). In the presence of Ca(2+), the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe. Peptides with proline in the P1' position are not substrates. Belongs to peptidase family M28.

Citations: [FundoianoHershc04, Arima06, BenMeir93, Spungin89, Gilboa00]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Arima06: Arima J, Uesugi Y, Iwabuchi M, Hatanaka T (2006). "Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica." Appl Microbiol Biotechnol 70(5);541-7. PMID: 16080009

BenMeir93: Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S (1993). "Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution." Eur J Biochem 212(1);107-12. PMID: 8444149

FundoianoHershc04: Fundoiano-Hershcovitz Y, Rabinovitch L, Langut Y, Reiland V, Shoham G, Shoham Y (2004). "Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus." FEBS Lett 571(1-3);192-6. PMID: 15280041

Gilboa00: Gilboa R, Greenblatt HM, Perach M, Spungin-Bialik A, Lessel U, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G (2000). "Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution." Acta Crystallogr D Biol Crystallogr 56(Pt 5);551-8. PMID: 10771423

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Spungin89: Spungin A, Blumberg S (1989). "Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme." Eur J Biochem 183(2);471-7. PMID: 2503378

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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