Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.11.24

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 3.4.11.24

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: aminopeptidase S

Enzyme Commission Synonyms: Mername-AA022 peptidase, SGAP, aminopeptidase (Streptomyces griseus), Streptomyces griseus aminopeptidase, S. griseus AP, double-zinc aminopeptidase

Enzyme Commission Summary:
Activated by Ca(2+). In the presence of Ca(2+), the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe. Peptides with proline in the P1' position are not substrates. Belongs to peptidase family M28.

Citations: [FundoianoHershc04, Arima06, BenMeir93, Spungin89, Gilboa00]

Relationship Links: BRENDA:EC:3.4.11.24 , ENZYME:EC:3.4.11.24 , IUBMB-ExplorEnz:EC:3.4.11.24


References

Arima06: Arima J, Uesugi Y, Iwabuchi M, Hatanaka T (2006). "Study on peptide hydrolysis by aminopeptidases from Streptomyces griseus, Streptomyces septatus and Aeromonas proteolytica." Appl Microbiol Biotechnol 70(5);541-7. PMID: 16080009

BenMeir93: Ben-Meir D, Spungin A, Ashkenazi R, Blumberg S (1993). "Specificity of Streptomyces griseus aminopeptidase and modulation of activity by divalent metal ion binding and substitution." Eur J Biochem 212(1);107-12. PMID: 8444149

FundoianoHershc04: Fundoiano-Hershcovitz Y, Rabinovitch L, Langut Y, Reiland V, Shoham G, Shoham Y (2004). "Identification of the catalytic residues in the double-zinc aminopeptidase from Streptomyces griseus." FEBS Lett 571(1-3);192-6. PMID: 15280041

Gilboa00: Gilboa R, Greenblatt HM, Perach M, Spungin-Bialik A, Lessel U, Wohlfahrt G, Schomburg D, Blumberg S, Shoham G (2000). "Interactions of Streptomyces griseus aminopeptidase with a methionine product analogue: a structural study at 1.53 A resolution." Acta Crystallogr D Biol Crystallogr 56(Pt 5);551-8. PMID: 10771423

Spungin89: Spungin A, Blumberg S (1989). "Streptomyces griseus aminopeptidase is a calcium-activated zinc metalloprotein. Purification and properties of the enzyme." Eur J Biochem 183(2);471-7. PMID: 2503378


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc14.