MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: Xaa-methyl-His dipeptidase

Enzyme Commission Synonyms: anserinase, aminoacyl-methylhistidine dipeptidase, acetylhistidine deacetylase, N-acetylhistidine deacetylase, α-N-acetyl-L-histidine aminohydrolase, X-methyl-His dipeptidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -21.005234Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Hydrolysis of anserine, carnosine, homocarnosine, glycyl-L-leucine and other dipeptides with broad specificity.

Is identical with acetylhistidine deacetylase.

Citations: [JONES55, Baslow67, Lenney78]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Baslow67: Baslow MH, Lenney JF (1967). "Alpha-N-acetyl-L-histidine amidohydrolase activity from the brain of the skipjack tuna Katsuwonus pelamis." Can J Biochem 45(2);337-40. PMID: 6067033

JONES55: JONES NR (1955). "The free amino acids of fish; 1-methylhistidine and beta-alanine liberation by skeletal muscle anserinase of codling (Gadus callarias)." Biochem J 60(1);81-7. PMID: 14363188

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lenney78: Lenney JF, Baslow MH, Sugiyama GH (1978). "Similarity of tuna N-acetylhistidine deacetylase and cod fish anserinase." Comp Biochem Physiol B 61(2);253-8. PMID: 318374

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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