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MetaCyc Reaction: 3.4.14.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.14.1

Enzymes and Genes:

Homo sapiens : dipeptidyl-aminopeptidase 1 complex Inferred from experiment : CTSC

Supersedes EC number: 3.4.4.9

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient

Enzyme Commission Primary Name: dipeptidyl-peptidase I

Enzyme Commission Synonyms: dipeptidyl aminopeptidase I, cathepsin C, dipeptidyl transferase, dipeptide arylamidase I, DAP I

Taxonomic Range: Metazoa

Enzyme Commission Summary:
A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).

Citations: [PLANTA64, Metroione66, McDonald69]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.4.14.1 , ENZYME:EC:3.4.14.1 , IUBMB-ExplorEnz:EC:3.4.14.1 , UniProt:RELATED-TO:P53634 , UniProt:RELATED-TO:P80067 , UniProt:RELATED-TO:Q7M4N9


References

McDonald69: McDonald JK, Zeitman BB, Reilly TJ, Ellis S (1969). "New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones." J Biol Chem 244(10);2693-709. PMID: 4306035

Metroione66: Metroione RM, Neves AG, Fruton JS (1966). "Purification and properties of dipeptidyl transferase (Cathepsin C)." Biochemistry 5(5);1597-604. PMID: 5961281

PLANTA64: PLANTA RJ, GORTER J, GRUBER M (1964). "THE CATALYTIC PROPERTIES OF CATHEPSIN C." Biochim Biophys Acta 89;511-9. PMID: 14209333


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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