|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Homo sapiens :||dipeptidyl-aminopeptidase 1 complex
Supersedes EC number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient
Enzyme Commission Primary Name: dipeptidyl-peptidase I
Enzyme Commission Synonyms: dipeptidyl aminopeptidase I, cathepsin C, dipeptidyl transferase, dipeptide arylamidase I, DAP I
Taxonomic Range: Metazoa
Enzyme Commission Summary:
A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).
McDonald69: McDonald JK, Zeitman BB, Reilly TJ, Ellis S (1969). "New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones." J Biol Chem 244(10);2693-709. PMID: 4306035
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