MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: dipeptidyl-peptidase IV

Enzyme Commission Synonyms: dipeptidyl aminopeptidase IV, Xaa-Pro-dipeptidyl-aminopeptidase, Gly-Pro naphthylamidase, postproline dipeptidyl aminopeptidase IV, lymphocyte antigen CD26, glycoprotein GP110, dipeptidyl peptidase IV, glycylproline aminopeptidase, X-prolyl dipeptidyl aminopeptidase, pep X, leukocyte antigen CD26, glycylprolyl dipeptidylaminopeptidase, dipeptidyl-peptide hydrolase, glycylprolyl aminopeptidase, dipeptidyl-aminopeptidase IV, DPP IV/CD26, amino acyl-prolyl dipeptidyl aminopeptidase, T cell triggering molecule Tp103, X-PDAP

Taxonomic Range: Fungi, Metazoa

Enzyme Commission Summary:
This enzyme catalyzes Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

A homodimer. An integral protein of the plasma membrane of lymphocytes and other mammalian cells, in peptidase family S9 (prolyl oligopeptidase family). The reaction is similar to that of the unrelated EC Xaa-Pro dipeptidyl-peptidase of lactococci.

Citations: [Misumi92, David93, Ikehara94]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P14740, UniProt:RELATED-TO:P22411, UniProt:RELATED-TO:P27487, UniProt:RELATED-TO:Q7M2P2


David93: David F, Bernard AM, Pierres M, Marguet D (1993). "Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases." J Biol Chem 268(23);17247-52. PMID: 8102366

Ikehara94: Ikehara Y, Ogata S, Misumi Y (1994). "Dipeptidyl-peptidase IV from rat liver." Methods Enzymol 244;215-27. PMID: 7845210

Misumi92: Misumi Y, Hayashi Y, Arakawa F, Ikehara Y (1992). "Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface." Biochim Biophys Acta 1131(3);333-6. PMID: 1352704

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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