MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: dipeptidyl carboxypeptidase IIInferred from experiment: dcp

Supersedes EC number:

Reaction Locations: periplasm (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: peptidyl-dipeptidase Dcp

Enzyme Commission Synonyms: dipeptidyl carboxypeptidase (Dcp), dipeptidyl carboxypeptidase

Taxonomic Range: Bacteria

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyse bonds in which P1' is Pro, or both P1 and P1' are Gly.

Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase in peptidase family M3 (thimet oligopeptidase family). Ac-Ala-|-Ala-Ala is a good test substrate [Conlin95]. Inhibited by captopril, as is peptidyl-dipeptidase A. Formerly EC, and included in EC, peptidyl-dipeptidase A.

Citations: [Deutch78, Yaron72, Yaron76, Henrich93]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P24171, UniProt:RELATED-TO:P27236


Conlin95: Conlin CA, Miller CG (1995). "Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium." Methods Enzymol 248;567-79. PMID: 7674945

Deutch78: Deutch CE, Soffer RL (1978). "Escherichia coli mutants defective in dipeptidyl carboxypeptidase." Proc Natl Acad Sci U S A 75(12);5998-6001. PMID: 216006

Henrich93: Henrich B, Becker S, Schroeder U, Plapp R (1993). "dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product." J Bacteriol 175(22);7290-300. PMID: 8226676

Yaron72: Yaron A, Mlynar D, Berger A (1972). "A dipeptidocarboxypeptidase from E. coli." Biochem Biophys Res Commun 47(4);897-902. PMID: 4554640

Yaron76: Yaron A (1976). "Dipeptidyl carboxypeptidase from Escherichia coli." Methods Enzymol 45;599-610. PMID: 13271

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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