|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655 :||dipeptidyl carboxypeptidase II
Supersedes EC number: 22.214.171.124
Reaction Locations: periplasmic space (sensu Gram-negative Bacteria)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: peptidyl-dipeptidase Dcp
Enzyme Commission Synonyms: dipeptidyl carboxypeptidase (Dcp), dipeptidyl carboxypeptidase
Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyse bonds in which P1' is Pro, or both P1 and P1' are Gly.
Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase in peptidase family M3 (thimet oligopeptidase family). Ac-Ala-|-Ala-Ala is a good test substrate [Conlin95]. Inhibited by captopril, as is peptidyl-dipeptidase A. Formerly EC 126.96.36.199, and included in EC 188.8.131.52, peptidyl-dipeptidase A.
Henrich93: Henrich B, Becker S, Schroeder U, Plapp R (1993). "dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product." J Bacteriol 175(22);7290-300. PMID: 8226676
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