Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 3.4.15.5

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 3.4.15.5

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: dipeptidyl carboxypeptidase IIInferred from experiment: dcp

Supersedes EC number: 3.4.15.3

Reaction Locations: periplasm (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: peptidyl-dipeptidase Dcp

Enzyme Commission Synonyms: dipeptidyl carboxypeptidase (Dcp), dipeptidyl carboxypeptidase

Taxonomic Range: Bacteria

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyse bonds in which P1' is Pro, or both P1 and P1' are Gly.

Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase in peptidase family M3 (thimet oligopeptidase family). Ac-Ala-|-Ala-Ala is a good test substrate [Conlin95]. Inhibited by captopril, as is peptidyl-dipeptidase A. Formerly EC 3.4.15.3, and included in EC 3.4.15.1, peptidyl-dipeptidase A.

Citations: [Deutch78, Yaron72, Yaron76, Henrich93]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.4.15.5, ENZYME:EC:3.4.15.5, IUBMB-ExplorEnz:EC:3.4.15.5, UniProt:RELATED-TO:P24171, UniProt:RELATED-TO:P27236


References

Conlin95: Conlin CA, Miller CG (1995). "Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium." Methods Enzymol 248;567-79. PMID: 7674945

Deutch78: Deutch CE, Soffer RL (1978). "Escherichia coli mutants defective in dipeptidyl carboxypeptidase." Proc Natl Acad Sci U S A 75(12);5998-6001. PMID: 216006

Henrich93: Henrich B, Becker S, Schroeder U, Plapp R (1993). "dcp gene of Escherichia coli: cloning, sequencing, transcript mapping, and characterization of the gene product." J Bacteriol 175(22);7290-300. PMID: 8226676

Yaron72: Yaron A, Mlynar D, Berger A (1972). "A dipeptidocarboxypeptidase from E. coli." Biochem Biophys Res Commun 47(4);897-902. PMID: 4554640

Yaron76: Yaron A (1976). "Dipeptidyl carboxypeptidase from Escherichia coli." Methods Enzymol 45;599-610. PMID: 13271


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun Feb 14, 2016, biocyc11.