Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.17.12

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.17.12

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: The left side is missing: R: 1 N: 1 C: 2 O: 1 H: 2

Enzyme Commission Primary Name: carboxypeptidase M

Enzyme Commission Synonyms: CPM

Standard Gibbs Free Energy (ΔrG in kcal/mol): -48.12524 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes cleavage of C-terminal arginine or lysine residues from polypeptides.

A membrane-bound enzyme optimally active at neutral pH. In peptidase family M14 (carboxypeptidase A family).

Citations: [Skidgel88, Deddish89, Skidgel89]

Relationship Links: BRENDA:EC:3.4.17.12 , ENZYME:EC:3.4.17.12 , IUBMB-ExplorEnz:EC:3.4.17.12


References

Deddish89: Deddish PA, Skidgel RA, Erdos EG (1989). "Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase)." Biochem J 261(1);289-91. PMID: 2775217

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Skidgel88: Skidgel RA (1988). "Basic carboxypeptidases: regulators of peptide hormone activity." Trends Pharmacol Sci 9(8);299-304. PMID: 3074547

Skidgel89: Skidgel RA, Davis RM, Tan F (1989). "Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones." J Biol Chem 264(4);2236-41. PMID: 2914904


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc14.