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MetaCyc Reaction: 3.4.21.49

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.21.49

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Protein: 1 O: 1 H: 1

Enzyme Commission Primary Name: hypodermin C

Enzyme Commission Synonyms: Hypoderma collagenase

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of proteins including native collagen at -|-Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment.

From the larva of a warble fly, Hypoderma lineatum. Little action on small molecule substrates of trypsin, chymotrypsin, elastase or microbial collagenases. In peptidase family S1 (trypsin family).

Citations: [Lecroisey79, Lecroisey85, Lecroisey87]

Relationship Links: BRENDA:EC:3.4.21.49 , ENZYME:EC:3.4.21.49 , IUBMB-ExplorEnz:EC:3.4.21.49 , UniProt:RELATED-TO:P08897


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lecroisey79: Lecroisey A, Boulard C, Keil B (1979). "Chemical and enzymatic characterization of the collagenase from the insect Hypoderma lineatum." Eur J Biochem 101(2);385-93. PMID: 230030

Lecroisey85: Lecroisey A, Keil B (1985). "Specificity of the collagenase from the insect Hypoderma lineatum." Eur J Biochem 152(1);123-30. PMID: 2995028

Lecroisey87: Lecroisey A, Gilles AM, De Wolf A, Keil B (1987). "Complete amino acid sequence of the collagenase from the insect Hypoderma lineatum." J Biol Chem 262(16);7546-51. PMID: 3034899


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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