Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.21.82

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.21.82

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: glutamyl endopeptidase II

Enzyme Commission Synonyms: GluSGP

Enzyme Commission Summary:
This enzyme catalyzes preferential cleavage: -Glu-|- >> -Asp-|- . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu-|-Asp- and -Glu-|-Pro- bonds is slow.

From Streptomyces griseus. A peptidase of family S1 (trypsin family). Inhibited by [Leu18→Glu]-modified turkey ovomucoid third domain

Citations: [Yoshida88, Komiyama91, Nagata91, Svendsen91, Breddam92]

Relationship Links: BRENDA:EC:3.4.21.82 , ENZYME:EC:3.4.21.82 , IUBMB-ExplorEnz:EC:3.4.21.82 , UniProt:RELATED-TO:Q03424 , UniProt:RELATED-TO:Q54211


References

Breddam92: Breddam K, Meldal M (1992). "Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching." Eur J Biochem 206(1);103-7. PMID: 1587264

Komiyama91: Komiyama T, Bigler TL, Yoshida N, Noda K, Laskowski M (1991). "Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus proteinase (GluSGP)." J Biol Chem 266(17);10727-30. PMID: 1674942

Nagata91: Nagata K, Yoshida N, Ogata F, Araki M, Noda K (1991). "Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8." J Biochem 110(6);859-62. PMID: 1794975

Svendsen91: Svendsen I, Jensen MR, Breddam K (1991). "The primary structure of the glutamic acid-specific protease of Streptomyces griseus." FEBS Lett 292(1-2);165-7. PMID: 1959600

Yoshida88: Yoshida N, Tsuruyama S, Nagata K, Hirayama K, Noda K, Makisumi S (1988). "Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase)." J Biochem 104(3);451-6. PMID: 3149277


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, biocyc14.