Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.21.86

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.21.86

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: limulus clotting enzyme

Enzyme Commission Synonyms: clotting enzyme

Enzyme Commission Summary:
This enzyme catalyzes selective cleavage of -Arg18-|- and -Arg47-|- bonds in coagulogen to form coagulin and fragments. From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)

Citations: [Muta90, Tokunaga91]

Relationship Links: BRENDA:EC:3.4.21.86 , ENZYME:EC:3.4.21.86 , IUBMB-ExplorEnz:EC:3.4.21.86 , UniProt:RELATED-TO:P21902


References

Muta90: Muta T, Hashimoto R, Miyata T, Nishimura H, Toh Y, Iwanaga S (1990). "Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization." J Biol Chem 265(36);22426-33. PMID: 2266134

Tokunaga91: Tokunaga F, Nakajima H, Iwanaga S (1991). "Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin." J Biochem 109(1);150-7. PMID: 2016264


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.