MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: limulus clotting enzyme

Enzyme Commission Synonyms: clotting enzyme

Taxonomic Range: Metazoa

Enzyme Commission Summary:
This enzyme catalyzes selective cleavage of -Arg18-|- and -Arg47-|- bonds in coagulogen to form coagulin and fragments. From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)

Citations: [Muta90, Tokunaga91]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P21902


Muta90: Muta T, Hashimoto R, Miyata T, Nishimura H, Toh Y, Iwanaga S (1990). "Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization." J Biol Chem 265(36);22426-33. PMID: 2266134

Tokunaga91: Tokunaga F, Nakajima H, Iwanaga S (1991). "Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin." J Biochem 109(1);150-7. PMID: 2016264

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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