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MetaCyc Reaction: 3.4.21.86

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.21.86

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: limulus clotting enzyme

Enzyme Commission Synonyms: clotting enzyme

Taxonomic Range: Metazoa

Enzyme Commission Summary:
This enzyme catalyzes selective cleavage of -Arg18-|- and -Arg47-|- bonds in coagulogen to form coagulin and fragments. From the hemocyte granules of horseshoe crabs Limulus and Tachypleus. Proclotting enzyme is activated by limulus clotting factor . In peptidase family S1 (trypsin family)

Citations: [Muta90, Tokunaga91]

Relationship Links: BRENDA:EC:3.4.21.86 , ENZYME:EC:3.4.21.86 , IUBMB-ExplorEnz:EC:3.4.21.86 , UniProt:RELATED-TO:P21902


References

Muta90: Muta T, Hashimoto R, Miyata T, Nishimura H, Toh Y, Iwanaga S (1990). "Proclotting enzyme from horseshoe crab hemocytes. cDNA cloning, disulfide locations, and subcellular localization." J Biol Chem 265(36);22426-33. PMID: 2266134

Tokunaga91: Tokunaga F, Nakajima H, Iwanaga S (1991). "Further studies on lipopolysaccharide-sensitive serine protease zymogen (factor C): its isolation from Limulus polyphemus hemocytes and identification as an intracellular zymogen activated by alpha-chymotrypsin, not by trypsin." J Biochem 109(1);150-7. PMID: 2016264


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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