Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
twitter

MetaCyc Reaction: 3.4.21.99

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.21.99

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: spermosin

Enzyme Commission Summary:
Hydrolyzes arginyl bonds, preferably with Pro in the P2 position.

The enzyme from the ascidian (Prochordate) Halocynthia roretzi is localised in the sperm head, and released during sperm activation.

A proline-rich region is involved in binding to the vitelline coat of the egg.

Belongs to peptidase family S1.

Citations: [Sawada84, Sawada84a, Sawada96, Sawada96a]

Relationship Links: BRENDA:EC:3.4.21.99 , ENZYME:EC:3.4.21.99 , IUBMB-ExplorEnz:EC:3.4.21.99


References

Sawada84: Sawada H, Yokosawa H, Ishii S (1984). "Purification and characterization of two types of trypsin-like enzymes from sperm of the ascidian (Prochordata) Halocynthia roretzi. Evidence for the presence of spermosin, a novel acrosin-like enzyme." J Biol Chem 259(5);2900-4. PMID: 6365918

Sawada84a: Sawada H, Yokosawa H, Someno T, Saino T, Ishii S (1984). "Evidence for the participation of two sperm proteases, spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme activities and fertilization." Dev Biol 105(1);246-9. PMID: 6381175

Sawada96: Sawada H, Iwasaki K, Kihara-Negishi F, Ariga H, Yokosawa H (1996). "Localization, expression, and the role in fertilization of spermosin, an ascidian sperm trypsin-like protease." Biochem Biophys Res Commun 222(2);499-504. PMID: 8670234

Sawada96a: Sawada H, Someno T (1996). "Substrate specificity of ascidian sperm trypsin-like proteases, spermosin and acrosin." Mol Reprod Dev 45(2);240-3. PMID: 8914083


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC14B.