Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.21.99

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.21.99

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: spermosin

Enzyme Commission Summary:
Hydrolyzes arginyl bonds, preferably with Pro in the P2 position.

The enzyme from the ascidian (Prochordate) Halocynthia roretzi is localised in the sperm head, and released during sperm activation.

A proline-rich region is involved in binding to the vitelline coat of the egg.

Belongs to peptidase family S1.

Citations: [Sawada84, Sawada84a, Sawada96, Sawada96a]

Relationship Links: BRENDA:EC:3.4.21.99 , ENZYME:EC:3.4.21.99 , IUBMB-ExplorEnz:EC:3.4.21.99


References

Sawada84: Sawada H, Yokosawa H, Ishii S (1984). "Purification and characterization of two types of trypsin-like enzymes from sperm of the ascidian (Prochordata) Halocynthia roretzi. Evidence for the presence of spermosin, a novel acrosin-like enzyme." J Biol Chem 259(5);2900-4. PMID: 6365918

Sawada84a: Sawada H, Yokosawa H, Someno T, Saino T, Ishii S (1984). "Evidence for the participation of two sperm proteases, spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme activities and fertilization." Dev Biol 105(1);246-9. PMID: 6381175

Sawada96: Sawada H, Iwasaki K, Kihara-Negishi F, Ariga H, Yokosawa H (1996). "Localization, expression, and the role in fertilization of spermosin, an ascidian sperm trypsin-like protease." Biochem Biophys Res Commun 222(2);499-504. PMID: 8670234

Sawada96a: Sawada H, Someno T (1996). "Substrate specificity of ascidian sperm trypsin-like proteases, spermosin and acrosin." Mol Reprod Dev 45(2);240-3. PMID: 8914083


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC14B.