Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.22.33

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.22.33

Supersedes EC numbers: 3.4.4.24, 3.4.22.5, 3.4.22.4

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: fruit bromelain

Enzyme Commission Synonyms: ananase, bromelase, bromelin, extranase, juice bromelain, pinase, pineapple enzyme, traumanase, fruit bromelain FA2

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg-|-NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain). From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain, is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin[Rowan90].

Citations: [Sasaki73, Yamada76a, Ota85]

Relationship Links: BRENDA:EC:3.4.22.33 , ENZYME:EC:3.4.22.33 , IUBMB-ExplorEnz:EC:3.4.22.33 , UniProt:RELATED-TO:O23791 , UniProt:RELATED-TO:O23800 , UniProt:RELATED-TO:O23801 , UniProt:RELATED-TO:O24641


References

Ota85: Ota S, Muta E, Katahira Y, Okamoto Y (1985). "Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains." J Biochem 98(1);219-28. PMID: 4044551

Rowan90: Rowan AD, Buttle DJ, Barrett AJ (1990). "The cysteine proteinases of the pineapple plant." Biochem J 266(3);869-75. PMID: 2327970

Sasaki73: Sasaki M, Kato T, Iida S (1973). "Antigenic determinant common to four kinds of thiol proteases of plant origin." J Biochem 74(3);635-7. PMID: 4127920

Yamada76a: Yamada F, Takahashi N, Murachi T (1976). "Purification and characterization of a proteinase from pineapple fruit, fruit bromelain FA2." J Biochem 79(6);1223-34. PMID: 956152


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 29, 2014, biocyc15.