|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Supersedes EC numbers: 220.127.116.11, 18.104.22.168, 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: fruit bromelain
Enzyme Commission Synonyms: ananase, bromelase, bromelin, extranase, juice bromelain, pinase, pineapple enzyme, traumanase, fruit bromelain FA2
Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of proteins with broad specificity for peptide bonds. Bz-Phe-Val-Arg-|-NHMec is a good synthetic substrate, but there is no action on Z-Arg-Arg-NHMec (c.f. stem bromelain). From the pineapple plant, Ananas comosus. Scarcely inhibited by chicken cystatin. Another cysteine endopeptidase, with similar action on small molecule substrates, pinguinain, is obtained from the related plant, Bromelia pinguin, but pinguinain differs from fruit bromelain in being inhibited by chicken cystatin[Rowan90].
Relationship Links: BRENDA:EC:126.96.36.199 , ENZYME:EC:188.8.131.52 , IUBMB-ExplorEnz:EC:184.108.40.206 , UniProt:RELATED-TO:O23791 , UniProt:RELATED-TO:O23800 , UniProt:RELATED-TO:O23801 , UniProt:RELATED-TO:O24641
Ota85: Ota S, Muta E, Katahira Y, Okamoto Y (1985). "Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains." J Biochem 98(1);219-28. PMID: 4044551
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