|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Supersedes EC number: 18.104.22.168
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1
Enzyme Commission Primary Name: clostripain
Enzyme Commission Synonyms: clostridiopeptidase B, clostridium histolyticum proteinase B, α-clostridipain, clostridiopeptidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 36.144756 [Latendresse13]
Enzyme Commission Summary:
This enzyme catalyzes preferential cleavege :Arg-|-, including Arg-|-Pro, but not Lys-.
From the bacterium Clostridium histolytic . It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family.
Gilles79: Gilles AM, Imhoff JM, Keil B (1979). "alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain." J Biol Chem 254(5);1462-8. PMID: 762145
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