Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
twitter

MetaCyc Reaction: 3.4.22.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.22.8

Supersedes EC number: 3.4.4.20

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1

Enzyme Commission Primary Name: clostripain

Enzyme Commission Synonyms: clostridiopeptidase B, clostridium histolyticum proteinase B, α-clostridipain, clostridiopeptidase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes preferential cleavege :Arg-|-, including Arg-|-Pro, but not Lys-.

From the bacterium Clostridium histolytic . It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family.

Citations: [Mitchell77, Gilles79, Gilles84]

Relationship Links: BRENDA:EC:3.4.22.8 , ENZYME:EC:3.4.22.8 , IUBMB-ExplorEnz:EC:3.4.22.8 , UniProt:RELATED-TO:P09870


References

Gilles79: Gilles AM, Imhoff JM, Keil B (1979). "alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain." J Biol Chem 254(5);1462-8. PMID: 762145

Gilles84: Gilles AM, Lecroisey A, Keil B (1984). "Primary structure of alpha-clostripain light chain." Eur J Biochem 145(3);469-76. PMID: 6391922

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mitchell77: Mitchell WM (1977). "Cleavage at arginine residues by clostripain." Methods Enzymol 47;165-70. PMID: 927173


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, biocyc14.