Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.22.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.22.8

Supersedes EC number: 3.4.4.20

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: clostripain

Enzyme Commission Synonyms: clostridiopeptidase B, clostridium histolyticum proteinase B, α-clostridipain, clostridiopeptidase

Enzyme Commission Summary:
This enzyme catalyzes preferential cleavege :Arg-|-, including Arg-|-Pro, but not Lys-.

From the bacterium Clostridium histolytic . It requires Ca2+ ions and is inhibited by EDTA. Type example of peptidase family.

Citations: [Mitchell77, Gilles79, Gilles84]

Relationship Links: BRENDA:EC:3.4.22.8 , ENZYME:EC:3.4.22.8 , IUBMB-ExplorEnz:EC:3.4.22.8 , UniProt:RELATED-TO:P09870


References

Gilles79: Gilles AM, Imhoff JM, Keil B (1979). "alpha-Clostripain. Chemical characterization, activity, and thiol content of the highly active form of clostripain." J Biol Chem 254(5);1462-8. PMID: 762145

Gilles84: Gilles AM, Lecroisey A, Keil B (1984). "Primary structure of alpha-clostripain light chain." Eur J Biochem 145(3);469-76. PMID: 6391922

Mitchell77: Mitchell WM (1977). "Cleavage at arginine residues by clostripain." Methods Enzymol 47;165-70. PMID: 927173


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.