MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1

Enzyme Commission Primary Name: aspergillopepsin II

Enzyme Commission Synonyms: proteinase A, proctase A, Aspergillus niger var. macrosporus aspartic proteinase

Taxonomic Range: Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes preferential cleavage in B chain of insulin : Asn3-|-Gln, Gly13-|-Ala, Tyr26-|-Thr.

Isolated from Aspergilus niger var.macrosporus, distinct from proteinase B (see aspergillopepsin I) in specificity and insensitivity to pepstatin. In peptidase family A4 (scytalidopepsin B family). Formerly included in EC

Citations: [Chang76, Iio76]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P24665


Chang76: Chang WJ, Horiuchi S, Takahashi K, Yamasaki M, Yamada Y (1976). "The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus." J Biochem 80(5);975-81. PMID: 12156

Iio76: Iio K, Yamasaki M (1976). "Specificity of acid proteinase A from Aspergillus niger var. macrosporus towards B-chain of performic acid oxidized bovine insulin." Biochim Biophys Acta 429(3);912-24. PMID: 1268233

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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