|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: aspergillopepsin II
Enzyme Commission Synonyms: proteinase A, proctase A, Aspergillus niger var. macrosporus aspartic proteinase
Enzyme Commission Summary:
This enzyme catalyzes preferential cleavage in B chain of insulin : Asn3-|-Gln, Gly13-|-Ala, Tyr26-|-Thr.
Isolated from Aspergilus niger var.macrosporus, distinct from proteinase B (see aspergillopepsin I) in specificity and insensitivity to pepstatin. In peptidase family A4 (scytalidopepsin B family). Formerly included in EC 184.108.40.206.
Chang76: Chang WJ, Horiuchi S, Takahashi K, Yamasaki M, Yamada Y (1976). "The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus." J Biochem 80(5);975-81. PMID: 12156
Iio76: Iio K, Yamasaki M (1976). "Specificity of acid proteinase A from Aspergillus niger var. macrosporus towards B-chain of performic acid oxidized bovine insulin." Biochim Biophys Acta 429(3);912-24. PMID: 1268233
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