Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 3.4.23.19

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.23.19

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: aspergillopepsin II

Enzyme Commission Synonyms: proteinase A, proctase A, Aspergillus niger var. macrosporus aspartic proteinase

Enzyme Commission Summary:
This enzyme catalyzes preferential cleavage in B chain of insulin : Asn3-|-Gln, Gly13-|-Ala, Tyr26-|-Thr.

Isolated from Aspergilus niger var.macrosporus, distinct from proteinase B (see aspergillopepsin I) in specificity and insensitivity to pepstatin. In peptidase family A4 (scytalidopepsin B family). Formerly included in EC 3.4.23.6.

Citations: [Chang76, Iio76]

Relationship Links: BRENDA:EC:3.4.23.19 , ENZYME:EC:3.4.23.19 , IUBMB-ExplorEnz:EC:3.4.23.19 , UniProt:RELATED-TO:P24665


References

Chang76: Chang WJ, Horiuchi S, Takahashi K, Yamasaki M, Yamada Y (1976). "The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus." J Biochem 80(5);975-81. PMID: 12156

Iio76: Iio K, Yamasaki M (1976). "Specificity of acid proteinase A from Aspergillus niger var. macrosporus towards B-chain of performic acid oxidized bovine insulin." Biochim Biophys Acta 429(3);912-24. PMID: 1268233


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc14.