MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1

Enzyme Commission Primary Name: mucorpepsin

Enzyme Commission Synonyms: Mucor rennin, Mucor acid proteinase, Mucor acid protease, Mucor miehei aspartic proteinase, Mucor miehei aspartic protease, Mucor aspartic proteinase, Mucor pusillus emporase, Fromase 100, Mucor pusillus rennin, Fromase 46TL, Mucor miehei rennin

Taxonomic Range: Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen.

Isolated from the zygomycete fungi Mucor pusillus and M. miehei. The two species variants show 83% sequence identity and are immunologically crossreactive. In peptidase family A1 (pepsin A family). Formerly included in EC

Citations: [Arima70, Sternberg72, Ottesen70, Baudys88, Oka73]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P00799, UniProt:RELATED-TO:P09177


Arima70: Arima, K.,, Yu, J., Iwasaki, S. (1970). "Milk-clotting enzyme from Mucor pusillus var. lindt." Methods Enzymol.

Baudys88: Baudys M, Foundling S, Pavlik M, Blundell T, Kostka V (1988). "Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment." FEBS Lett 235(1-2);271-4. PMID: 3042459

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Oka73: Oka, T., Ishino, K., Tsuzuki, H., Morihara, K., Arima, K. (1973). "On the specificity of a rennin-like enzyme from Mucor pusillus." Agric. Biol. Chem.

Ottesen70: Ottesen, M., Svendsen, I. (1970). "The subtilisins." Methods Enzymol.

Sternberg72: Sternberg M (1972). "Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease." Biochim Biophys Acta 285(2);383-92. PMID: 4573298

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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