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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.4.23.23

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.23.23

Supersedes EC number: 3.4.4.17

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: mucorpepsin

Enzyme Commission Synonyms: Mucor rennin, Mucor acid proteinase, Mucor acid protease, Mucor miehei aspartic proteinase, Mucor miehei aspartic protease, Mucor aspartic proteinase, Mucor pusillus emporase, Fromase 100, Mucor pusillus rennin, Fromase 46TL, Mucor miehei rennin

Enzyme Commission Summary:
This enzyme catalyzes hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen.

Isolated from the zygomycete fungi Mucor pusillus and M. miehei. The two species variants show 83% sequence identity and are immunologically crossreactive. In peptidase family A1 (pepsin A family). Formerly included in EC 3.4.23.6

Citations: [Arima70, Sternberg72, Ottesen70, Baudys88, Oka73]

Relationship Links: BRENDA:EC:3.4.23.23 , ENZYME:EC:3.4.23.23 , IUBMB-ExplorEnz:EC:3.4.23.23 , UniProt:RELATED-TO:P00799 , UniProt:RELATED-TO:P09177


References

Arima70: Arima, K.,, Yu, J., Iwasaki, S. (1970). "Milk-clotting enzyme from Mucor pusillus var. lindt." Methods Enzymol.

Baudys88: Baudys M, Foundling S, Pavlik M, Blundell T, Kostka V (1988). "Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment." FEBS Lett 235(1-2);271-4. PMID: 3042459

Oka73: Oka, T., Ishino, K., Tsuzuki, H., Morihara, K., Arima, K. (1973). "On the specificity of a rennin-like enzyme from Mucor pusillus." Agric. Biol. Chem.

Ottesen70: Ottesen, M., Svendsen, I. (1970). "The subtilisins." Methods Enzymol.

Sternberg72: Sternberg M (1972). "Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease." Biochim Biophys Acta 285(2);383-92. PMID: 4573298


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc13.