MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Pseudomonas aeruginosa: elastase: lasB

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1

Enzyme Commission Primary Name: pseudolysin

Enzyme Commission Synonyms: Pseudomonas elastase, Pseudomonas aeruginosa neutral metalloproteinase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catalyzes the hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.

The protein belongs to the Ipeptidase family M4. It has been characterized rrom the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage [Nishino80, Dreyfus86, Bever88, Black90].

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P14756


Bever88: Bever RA, Iglewski BH (1988). "Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene." J Bacteriol 170(9);4309-14. PMID: 2842313

Black90: Black WJ, Quinn FD, Tompkins LS (1990). "Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase." J Bacteriol 172(5);2608-13. PMID: 2110146

Dreyfus86: Dreyfus LA, Iglewski BH (1986). "Purification and characterization of an extracellular protease of Legionella pneumophila." Infect Immun 51(3);736-43. PMID: 3512431

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nishino80: Nishino N, Powers JC (1980). "Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand." J Biol Chem 255(8);3482-6. PMID: 6767718

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Jan 3, 2002, biocyc12.