Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.4.24.26

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.24.26

Enzymes and Genes:
elastase : lasB ( Pseudomonas aeruginosa )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: pseudolysin

Enzyme Commission Synonyms: Pseudomonas elastase, Pseudomonas aeruginosa neutral metalloproteinase

Enzyme Commission Summary:
This enzyme catalyzes the hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.

The protein belongs to the Ipeptidase family M4. It has been characterized rrom the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage [Nishino80, Dreyfus86, Bever88, Black90].

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.4.24.26 , ENZYME:EC:3.4.24.26 , IUBMB-ExplorEnz:EC:3.4.24.26 , UniProt:RELATED-TO:P14756


References

Bever88: Bever RA, Iglewski BH (1988). "Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene." J Bacteriol 170(9);4309-14. PMID: 2842313

Black90: Black WJ, Quinn FD, Tompkins LS (1990). "Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase." J Bacteriol 172(5);2608-13. PMID: 2110146

Dreyfus86: Dreyfus LA, Iglewski BH (1986). "Purification and characterization of an extracellular protease of Legionella pneumophila." Infect Immun 51(3);736-43. PMID: 3512431

Nishino80: Nishino N, Powers JC (1980). "Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand." J Biol Chem 255(8);3482-6. PMID: 6767718


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14B.