|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Pseudomonas aeruginosa :||elastase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Protein: 1 O: 1 H: 1
Enzyme Commission Primary Name: pseudolysin
Enzyme Commission Synonyms: Pseudomonas elastase, Pseudomonas aeruginosa neutral metalloproteinase
Taxonomic Range: Bacteria
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 36.144756 [Latendresse13]
Enzyme Commission Summary:
This enzyme catalyzes the hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects.
The protein belongs to the Ipeptidase family M4. It has been characterized rrom the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage [Nishino80, Dreyfus86, Bever88, Black90].
Black90: Black WJ, Quinn FD, Tompkins LS (1990). "Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase." J Bacteriol 172(5);2608-13. PMID: 2110146
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