MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient

Enzyme Commission Primary Name: adamalysin

Enzyme Commission Synonyms: Crotalus adamanteus metalloendopeptidase, proteinase I and II, Crotalus adamanteus venom proteinase II, adamalysin II

Taxonomic Range: Metazoa

Enzyme Commission Summary:
Cleavage of Phe1| Val, His5| Leu, His10| Leu, Ala14| Leu, Leu15| Tyr, and Tyr16| Leu of insulin B chain.

From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family).

Citations: [Kurecki78]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:Q7LZP2


Kurecki78: Kurecki T, Laskowski M, Kress LF (1978). "Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor." J Biol Chem 253(22);8340-5. PMID: 309470

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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