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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.4.24.46

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.24.46

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: adamalysin

Enzyme Commission Synonyms: Crotalus adamanteus metalloendopeptidase, proteinase I and II, Crotalus adamanteus venom proteinase II, adamalysin II

Enzyme Commission Summary:
Cleavage of Phe1| Val, His5| Leu, His10| Leu, Ala14| Leu, Leu15| Tyr, and Tyr16| Leu of insulin B chain.

From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family).

Citations: [Kurecki78]

Relationship Links: BRENDA:EC:3.4.24.46 , ENZYME:EC:3.4.24.46 , IUBMB-ExplorEnz:EC:3.4.24.46 , UniProt:RELATED-TO:Q7LZP2


References

Kurecki78: Kurecki T, Laskowski M, Kress LF (1978). "Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor." J Biol Chem 253(22);8340-5. PMID: 309470


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC13B.