|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient
Enzyme Commission Primary Name: adamalysin
Enzyme Commission Synonyms: Crotalus adamanteus metalloendopeptidase, proteinase I and II, Crotalus adamanteus venom proteinase II, adamalysin II
Taxonomic Range: Metazoa
Enzyme Commission Summary:
Cleavage of Phe1| Val, His5| Leu, His10| Leu, Ala14| Leu, Leu15| Tyr, and Tyr16| Leu of insulin B chain.
From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family).
Kurecki78: Kurecki T, Laskowski M, Kress LF (1978). "Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor." J Biol Chem 253(22);8340-5. PMID: 309470
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