|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient
Enzyme Commission Primary Name: ruberlysin
Enzyme Commission Synonyms: Crotalus ruber metalloendopeptidase II, hemorrhagic toxin II
Taxonomic Range: Metazoa
Enzyme Commission Summary:
This enzyme catalyzes cleavage of His10-|-Leu, Ala14-|-Leu, Tyr16-|-Leu and Gly23-|-Phe bonds in the B chain of insulin; His-|-Pro, Pro-|-Phe, and Trp-|-Ser of angiotensin I; and Gly-|-Phe of Met enkephalin.
A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family).
Mori87: Mori N, Nikai T, Sugihara H, Tu AT (1987). "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom." Arch Biochem Biophys 253(1);108-21. PMID: 2949699
Takeya90: Takeya H, Onikura A, Nikai T, Sugihara H, Iwanaga S (1990). "Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber." J Biochem 108(5);711-9. PMID: 2081731
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493