Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.4.24.72

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.4.24.72

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: fibrolase

Enzyme Commission Synonyms: fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase

Enzyme Commission Summary:
This enzyme catayzes hydrolysis of -Ala14-|-Leu- in insulin B chain and -Lys413-|-Leu- in A-chain of fibrinogen.

A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family).

Citations: [Retzios88, Guan91, Randolph92, Loayza94, Retzios94]

Relationship Links: BRENDA:EC:3.4.24.72 , ENZYME:EC:3.4.24.72 , IUBMB-ExplorEnz:EC:3.4.24.72


References

Guan91: Guan AL, Retzios AD, Henderson GN, Markland FS (1991). "Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)." Arch Biochem Biophys 289(2);197-207. PMID: 1898066

Loayza94: Loayza SL, Trikha M, Markland FS, Riquelme P, Kuo J (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities." J Chromatogr B Biomed Appl 662(2);227-43. PMID: 7719479

Randolph92: Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS, Masiarz FR (1992). "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom." Protein Sci 1(5);590-600. PMID: 1304358

Retzios88: Retzios AD, Markland FS (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems." Thromb Res 52(6);541-52. PMID: 3232124

Retzios94: Retzios AD, Markland FS (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin." Thromb Res 74(4);355-67. PMID: 8085237


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14A.