MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1

Enzyme Commission Primary Name: fibrolase

Enzyme Commission Synonyms: fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 36.144756Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme catayzes hydrolysis of -Ala14-|-Leu- in insulin B chain and -Lys413-|-Leu- in A-chain of fibrinogen.

A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake ( Agkistrodon contortix contortix). In peptidase family M12 (astacin family).

Citations: [Retzios88, Guan91, Randolph92, Loayza94, Retzios94]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Guan91: Guan AL, Retzios AD, Henderson GN, Markland FS (1991). "Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)." Arch Biochem Biophys 289(2);197-207. PMID: 1898066

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Loayza94: Loayza SL, Trikha M, Markland FS, Riquelme P, Kuo J (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities." J Chromatogr B Biomed Appl 662(2);227-43. PMID: 7719479

Randolph92: Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS, Masiarz FR (1992). "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom." Protein Sci 1(5);590-600. PMID: 1304358

Retzios88: Retzios AD, Markland FS (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems." Thromb Res 52(6);541-52. PMID: 3232124

Retzios94: Retzios AD, Markland FS (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin." Thromb Res 74(4);355-67. PMID: 8085237

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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