|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: The left side is missing: Peptides: 2 . The right side is missing: Proteins: 1 O: 1 H: 1
Enzyme Commission Primary Name: fibrolase
Enzyme Commission Synonyms: fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase
Taxonomic Range: Metazoa
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 36.144756 [Latendresse13]
Enzyme Commission Summary:
This enzyme catayzes hydrolysis of -Ala14-|-Leu- in insulin B chain and -Lys413-|-Leu- in A-chain of fibrinogen.
A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family).
Guan91: Guan AL, Retzios AD, Henderson GN, Markland FS (1991). "Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)." Arch Biochem Biophys 289(2);197-207. PMID: 1898066
Loayza94: Loayza SL, Trikha M, Markland FS, Riquelme P, Kuo J (1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities." J Chromatogr B Biomed Appl 662(2);227-43. PMID: 7719479
Randolph92: Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS, Masiarz FR (1992). "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom." Protein Sci 1(5);590-600. PMID: 1304358
Retzios88: Retzios AD, Markland FS (1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems." Thromb Res 52(6);541-52. PMID: 3232124
Retzios94: Retzios AD, Markland FS (1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin." Thromb Res 74(4);355-67. PMID: 8085237
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