|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: microtubule-severing ATPase
Enzyme Commission Synonyms: Katanin
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -7.598877 [Latendresse13]
Enzyme Commission Summary:
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
Instance reaction of [a nucleoside triphosphate + H2O → a nucleoside diphosphate + phosphate + H+] (22.214.171.124):
i1: ATP + H2O → ADP + phosphate + H+ (126.96.36.199)
Hartman98: Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit." Cell 93(2);277-87. PMID: 9568719
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493