MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: microtubule-severing ATPase

Enzyme Commission Synonyms: Katanin

Taxonomic Range: Viridiplantae, Metazoa

Enzyme Commission Summary:
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

Citations: [McNally93, Hartman98]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 05-Feb-2015 by Caspi R, SRI International


Hartman98: Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit." Cell 93(2);277-87. PMID: 9568719

McNally93: McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules." Cell 75(3);419-29. PMID: 8221885

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc12.