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MetaCyc Reaction: 3.6.4.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.4.3

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: microtubule-severing ATPase

Enzyme Commission Synonyms: Katanin

Taxonomic Range: Viridiplantae , Metazoa

Enzyme Commission Summary:
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

Citations: [McNally93, Hartman98]

Relationship Links: BRENDA:EC:3.6.4.3 , ENZYME:EC:3.6.4.3 , IUBMB-ExplorEnz:EC:3.6.4.3

Credits:
Created 05-Feb-2015 by Caspi R , SRI International


References

Hartman98: Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit." Cell 93(2);277-87. PMID: 9568719

McNally93: McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules." Cell 75(3);419-29. PMID: 8221885


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jul 7, 2015, biocyc11.