Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.6.4.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.4.3

Enzymes and Genes:
nucleoside-triphosphatase : NTP1 ( Pisum sativum )
cancer-related nucleoside-triphosphatase : NTPCR ( Homo sapiens )
nucleoside-triphosphatase : THEP1 ( Aquifex aeolicus VF5 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: microtubule-severing ATPase

Enzyme Commission Synonyms: Katanin

Standard Gibbs Free Energy (ΔrG in kcal/mol): -7.598877 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

Citations: [McNally93, Hartman98]

Gene-Reaction Schematic: ?

Instance reaction of [a nucleoside triphosphate + H2O → a nucleoside diphosphate + phosphate + H+] (3.6.1.15):
i1: ATP + H2O → ADP + phosphate + H+ (3.6.4.3)

Unification Links: KEGG:R00086 , Rhea:13065

Relationship Links: BRENDA:EC:3.6.4.3 , ENZYME:EC:3.6.4.3 , IUBMB-ExplorEnz:EC:3.6.4.3


References

Hartman98: Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit." Cell 93(2);277-87. PMID: 9568719

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

McNally93: McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules." Cell 75(3);419-29. PMID: 8221885


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, biocyc11.