Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.6.4.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.6.4.3

Enzymes and Genes:
nucleoside-triphosphatase : NTP1 ( Pisum sativum )
cancer-related nucleoside-triphosphatase : NTPCR ( Homo sapiens )
nucleoside-triphosphatase : THEP1 ( Aquifex aeolicus VF5 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: microtubule-severing ATPase

Enzyme Commission Synonyms: Katanin

Standard Gibbs Free Energy (ΔrG in kcal/mol): -7.598877 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.

Citations: [McNally93, Hartman98]

Gene-Reaction Schematic: ?

Instance reaction of [a nucleoside triphosphate + H2O → a nucleoside diphosphate + phosphate + H+] (3.6.1.15):
i1: ATP + H2O → ADP + phosphate + H+ (3.6.4.3)

Unification Links: KEGG:R00086 , Rhea:13065

Relationship Links: BRENDA:EC:3.6.4.3 , ENZYME:EC:3.6.4.3 , IUBMB-ExplorEnz:EC:3.6.4.3


References

Hartman98: Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit." Cell 93(2);277-87. PMID: 9568719

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

McNally93: McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules." Cell 75(3);419-29. PMID: 8221885


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.