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MetaCyc Reaction: 3.7.1.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.7.1.8

Enzymes and Genes:

Pseudomonas nitroreducens : 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoate hydrolase [multifunctional] Inferred from experiment : hbpD
Rhodococcus jostii RHA1 : 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase Inferred from experiment : bphD

In Pathway: biphenyl degradation , 2-hydroxybiphenyl degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase

Enzyme Commission Synonyms: HOHPDA hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.087128 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.

Citations: [Omori86]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02606 , Rhea:17161

Relationship Links: BRENDA:EC:3.7.1.8 , ENZYME:EC:3.7.1.8 , IUBMB-ExplorEnz:EC:3.7.1.8 , UniProt:RELATED-TO:P17548 , UniProt:RELATED-TO:Q52036

Credits:
Revised 17-Apr-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Omori86: Omori, T., Sugimura, K., Ishigooka, H., Minoda, Y. (1986). "Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl." Agric. Biol. Chem. 50: 931-937.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc14.