MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Pseudomonas nitroreducens: 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoate hydrolase [multifunctional]Inferred from experiment: hbpD
Rhodococcus jostii RHA1: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolaseInferred from experiment: bphD

In Pathway: biphenyl degradation, 2-hydroxybiphenyl degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase

Enzyme Commission Synonyms: HOHPDA hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.087128Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.

Citations: [Omori86]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02606, Rhea:17161

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P17548, UniProt:RELATED-TO:Q52036

Revised 17-Apr-2012 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Omori86: Omori, T., Sugimura, K., Ishigooka, H., Minoda, Y. (1986). "Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl." Agric. Biol. Chem. 50: 931-937.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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