Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.7.1.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.7.1.8

Enzymes and Genes:
2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoate hydrolase [multifunctional] Inferred from experiment : hbpD ( Pseudomonas nitroreducens )
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase Inferred from experiment : bphD ( Rhodococcus jostii RHA1 )

In Pathway: biphenyl degradation , 2-hydroxybiphenyl degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase

Enzyme Commission Synonyms: HOHPDA hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.087128 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.

Citations: [Omori86]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02606 , Rhea:17161

Relationship Links: BRENDA:EC:3.7.1.8 , ENZYME:EC:3.7.1.8 , IUBMB-ExplorEnz:EC:3.7.1.8 , UniProt:RELATED-TO:P17548 , UniProt:RELATED-TO:Q52036

Credits:
Revised 17-Apr-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Omori86: Omori, T., Sugimura, K., Ishigooka, H., Minoda, Y. (1986). "Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl." Agric. Biol. Chem. 50: 931-937.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 21, 2014, BIOCYC13B.