Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015
Join us at the Metabolomics Conference tutorial
June 28th 2015

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: ,

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name for (R)-2-haloacid dehalogenase

Enzyme Commission Synonyms for 2-haloalkanoic acid dehalogenase[ambiguous], 2-haloalkanoid acid halidohydrolase[ambiguous], D-2-haloacid dehalogenase, D-DEX

Enzyme Commission Primary Name for 2-haloacid dehalogenase (configuration-inverting)

Enzyme Commission Synonyms for 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, DL-2-haloacid dehalogenase, DL-2-haloacid dehalogenase (inversion of configuration), DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEXi, (R,S)-2-haloacid dehalogenase (configuration-inverting)

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.2382355 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary for
Acts on acids of short chain lengths, C(2) to C(4), with inversion

Enzyme Commission Summary for
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less.

See also EC, (S)-2-haloacid dehalogenase, EC, (R)-2-haloacid dehalogenase, and EC, 2-haloacid dehalogenase (configuration-retaining).

Citations: [Smith90, Weightman82, Cairns96, Liu94a, HEPPEL48, Motosugi82, Motosugi82a]

Unification Links: KEGG:R07308 , KEGG:R07308

Relationship Links: BRENDA:EC: , BRENDA:EC: , ENZYME:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , IUBMB-ExplorEnz:EC:


Cairns96: Cairns SS, Cornish A, Cooper RA (1996). "Cloning, sequencing and expression in Escherichia coli of two Rhizobium sp. genes encoding haloalkanoate dehalogenases of opposite stereospecificity." Eur J Biochem 235(3);744-9. PMID: 8654424

HEPPEL48: HEPPEL LA, PORTERFIELD VT (1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds." J Biol Chem 176(2);763-9. PMID: 18889931

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Liu94a: Liu JQ, Kurihara T, Hasan AK, Nardi-Dei V, Koshikawa H, Esaki N, Soda K (1994). "Purification and characterization of thermostable and nonthermostable 2-haloacid dehalogenases with different stereospecificities from Pseudomonas sp. strain YL." Appl Environ Microbiol 60(7);2389-93. PMID: 8074519

Motosugi82: Motosugi K, Esaki N, Soda K (1982). "Purification and properties of a new enzyme, DL-2-haloacid dehalogenase, from Pseudomonas sp." J Bacteriol 150(2);522-7. PMID: 7068529

Motosugi82a: Motosugi K, Esaki N, Soda K (1982). "Bacterial assimilation of D- and L-2-chloropropionates and occurrence of a new dehalogenase." Arch Microbiol 131(3);179-83. PMID: 7103659

Smith90: Smith JM, Harrison K, Colby J (1990). "Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23." J Gen Microbiol 136(5);881-6. PMID: 2380688

Weightman82: Weightman AJ, Weightman AL, Slater JH (1982). "Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms." J Gen Microbiol 128(8);1755-62. PMID: 7142958

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jun 30, 2015, biocyc14.