MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana ler: γ-hydroxybutyrate dehydrogenase: AtGHBDH
Clostridium aminobutyricum: 4-hydroxybutyrate dehydrogenaseInferred from experiment: abfH
Clostridium kluyveri: 4-hydroxybutyrate dehydrogenaseInferred from experiment: 4hbD
Escherichia coli K-12 substr. MG1655: 3-sulfolactaldehyde reductaseInferred from experiment: yihU

In Pathway: succinate fermentation to butanoate, 4-aminobutanoate degradation V

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+ (1.1.1.-)

Enzyme Commission Primary Name: 4-hydroxybutyrate dehydrogenase

Enzyme Commission Synonyms: γ-hydroxybutyrate dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 2.541809Inferred by computational analysis [Latendresse13]

Citations: [NIRENBERG60]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+] (1.1.1.-):
i1: 4-hydroxybutanoate + NADP+ ← succinate semialdehyde + NADPH + H+ (

i2: 4-hydroxybutanoate + NAD+ ↔ succinate semialdehyde + NADH + H+ (

Unification Links: KEGG:R01644, Rhea:23948

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:Q59104


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

NIRENBERG60: NIRENBERG MW, JAKOBY WB (1960). "Enzymatic utilization of gamma-hydroxybutyric acid." J Biol Chem 235;954-60. PMID: 14427301

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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