|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Arabidopsis thaliana ler:||γ-hydroxybutyrate dehydrogenase: AtGHBDH|
|Clostridium aminobutyricum:||4-hydroxybutyrate dehydrogenase: abfH|
|Clostridium kluyveri:||4-hydroxybutyrate dehydrogenase: 4hbD|
|Escherichia coli K-12 substr. MG1655:||3-sulfolactaldehyde reductase: yihU|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+ (1.1.1.-)
Enzyme Commission Primary Name: 4-hydroxybutyrate dehydrogenase
Enzyme Commission Synonyms: γ-hydroxybutyrate dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 2.541809 [Latendresse13]
Instance reactions of [4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+] (1.1.1.-):
i1: 4-hydroxybutanoate + NADP+ ← succinate semialdehyde + NADPH + H+ (1.1.1.co)
i2: 4-hydroxybutanoate + NAD+ ↔ succinate semialdehyde + NADH + H+ (18.104.22.168)
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