MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana ler : γ-hydroxybutyrate dehydrogenase : AtGHBDH
Clostridium aminobutyricum : 4-hydroxybutyrate dehydrogenase Inferred from experiment : abfH
Clostridium kluyveri : 4-hydroxybutyrate dehydrogenase Inferred from experiment : 4hbD
Escherichia coli K-12 substr. MG1655 : 3-sulfolactaldehyde reductase Inferred from experiment : yihU

In Pathway: succinate fermentation to butanoate , 4-aminobutanoate degradation V

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+ (1.1.1.-)

Enzyme Commission Primary Name: 4-hydroxybutyrate dehydrogenase

Enzyme Commission Synonyms: γ-hydroxybutyrate dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 2.541809 Inferred by computational analysis [Latendresse13]

Citations: [NIRENBERG60]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+] (1.1.1.-):
i1: 4-hydroxybutanoate + NADP+ ← succinate semialdehyde + NADPH + H+ (

i2: 4-hydroxybutanoate + NAD+ ↔ succinate semialdehyde + NADH + H+ (

Unification Links: KEGG:R01644 , Rhea:23948

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:Q59104


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

NIRENBERG60: NIRENBERG MW, JAKOBY WB (1960). "Enzymatic utilization of gamma-hydroxybutyric acid." J Biol Chem 235;954-60. PMID: 14427301

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, BIOCYC14B.