|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Arabidopsis thaliana ler :||γ-hydroxybutyrate dehydrogenase
|Clostridium aminobutyricum :||4-hydroxybutyrate dehydrogenase
|Clostridium kluyveri :||4-hydroxybutyrate dehydrogenase
|Escherichia coli K-12 substr. MG1655 :||3-sulfolactaldehyde reductase
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+ (1.1.1.-)
Enzyme Commission Primary Name: 4-hydroxybutyrate dehydrogenase
Enzyme Commission Synonyms: γ-hydroxybutyrate dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 2.541809 [Latendresse13]
Instance reactions of [4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+] (1.1.1.-):
i1: 4-hydroxybutanoate + NADP+ ← succinate semialdehyde + NADPH + H+ (1.1.1.co)
i2: 4-hydroxybutanoate + NAD+ ↔ succinate semialdehyde + NADH + H+ (22.214.171.124)
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493