|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
3-sulfolactaldehyde reductase : yihU ( Escherichia coli K-12 substr. MG1655 )
4-hydroxybutyrate dehydrogenase : abfH ( Clostridium aminobutyricum )
4-hydroxybutyrate dehydrogenase : 4hbD ( Clostridium kluyveri )
γ-hydroxybutyrate dehydrogenase : AtGHBDH ( Arabidopsis thaliana ler )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+ (1.1.1.-)
Enzyme Commission Primary Name: 4-hydroxybutyrate dehydrogenase
Enzyme Commission Synonyms: γ-hydroxybutyrate dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 2.541809 [Latendresse13]
Instance reactions of [4-hydroxybutanoate + NAD(P)+ ← succinate semialdehyde + NAD(P)H + H+] (1.1.1.-):
i1: 4-hydroxybutanoate + NADP+ ← succinate semialdehyde + NADPH + H+ (1.1.1.co)
i2: 4-hydroxybutanoate + NAD+ ↔ succinate semialdehyde + NADH + H+ (184.108.40.206)
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