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MetaCyc Reaction: 4.1.1.72

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 4.1.1.72

Enzymes and Genes:

Saccharomyces cerevisiae: 2-keto-methylvalerate decarboxylaseInferred from experiment: THI3
2-oxo acid decarboxylaseInferred from experiment: ARO10
pyruvate decarboxylase 3Inferred from experiment: PDC6
pyruvate decarboxylase 2Inferred from experiment: PDC5
pyruvate decarboxylase 1Inferred from experiment: PDC1

In Pathway: L-isoleucine degradation II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: branched-chain-2-oxoacid decarboxylase

Enzyme Commission Synonyms: branched-chain oxo acid decarboxylase, branched-chain α-keto acid decarboxylase, branched-chain keto acid decarboxylase, BCKA, (3S)-3-methyl-2-oxopentanoate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.465889Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.

Citations: [Oku88]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a 2-oxo carboxylate + H+ = an aldehyde + CO2] (4.1.1.1):
i1: pyruvate + H+ → acetaldehyde + CO2 (4.1.1.1)

Unification Links: KEGG:R03894, Rhea:21108

Relationship Links: BRENDA:EC:4.1.1.72, ENZYME:EC:4.1.1.72, IUBMB-ExplorEnz:EC:4.1.1.72


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Oku88: Oku H, Kaneda T (1988). "Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase." J Biol Chem 263(34);18386-96. PMID: 3142877


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Feb 12, 2016, biocyc13.