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MetaCyc Reaction: 4.1.1.72

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.72

Enzymes and Genes:
pyruvate decarboxylase 1 Inferred from experiment : PDC1 ( Saccharomyces cerevisiae )
pyruvate decarboxylase 2 Inferred from experiment : PDC5 ( Saccharomyces cerevisiae )
pyruvate decarboxylase 3 Inferred from experiment : PDC6 ( Saccharomyces cerevisiae )
2-oxo acid decarboxylase Inferred from experiment : ARO10 ( Saccharomyces cerevisiae )
2-keto-methylvalerate decarboxylase Inferred from experiment : THI3 ( Saccharomyces cerevisiae )

In Pathway: L-isoleucine degradation II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: branched-chain-2-oxoacid decarboxylase

Enzyme Commission Synonyms: branched-chain oxo acid decarboxylase, branched-chain α-keto acid decarboxylase, branched-chain keto acid decarboxylase, BCKA, (3S)-3-methyl-2-oxopentanoate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.465889 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.

Citations: [Oku88]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a 2-oxo carboxylate + H+ = an aldehyde + CO2] (4.1.1.1):
i1: pyruvate + H+ → acetaldehyde + CO2 (4.1.1.1)

Unification Links: KEGG:R03894 , Rhea:21108

Relationship Links: BRENDA:EC:4.1.1.72 , ENZYME:EC:4.1.1.72 , IUBMB-ExplorEnz:EC:4.1.1.72


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Oku88: Oku H, Kaneda T (1988). "Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase." J Biol Chem 263(34);18386-96. PMID: 3142877


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Mar 30, 2015, BIOCYC13B.