Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.1.72

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.72

Enzymes and Genes:
pyruvate decarboxylase 1 Inferred from experiment : PDC1 ( Saccharomyces cerevisiae )
pyruvate decarboxylase 2 Inferred from experiment : PDC5 ( Saccharomyces cerevisiae )
pyruvate decarboxylase 3 Inferred from experiment : PDC6 ( Saccharomyces cerevisiae )
2-oxo acid decarboxylase Inferred from experiment : ARO10 ( Saccharomyces cerevisiae )
2-keto-methylvalerate decarboxylase Inferred from experiment : THI3 ( Saccharomyces cerevisiae )

In Pathway: isoleucine degradation II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: branched-chain-2-oxoacid decarboxylase

Enzyme Commission Synonyms: branched-chain oxo acid decarboxylase, branched-chain α-keto acid decarboxylase, branched-chain keto acid decarboxylase, BCKA, (3S)-3-methyl-2-oxopentanoate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.465889 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.

Citations: [Oku88]

Gene-Reaction Schematic: ?

Instance reaction of [a 2-oxo carboxylate + H+ = an aldehyde + CO2] (4.1.1.1):
i1: pyruvate + H+ → acetaldehyde + CO2 (4.1.1.1)

Unification Links: KEGG:R03894 , Rhea:21108

Relationship Links: BRENDA:EC:4.1.1.72 , ENZYME:EC:4.1.1.72 , IUBMB-ExplorEnz:EC:4.1.1.72


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Oku88: Oku H, Kaneda T (1988). "Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase." J Biol Chem 263(34);18386-96. PMID: 3142877


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.