Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.1.81

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.81

Enzymes and Genes:
threonine-phosphate decarboxylase : cobC ( Pseudomonas denitrificans )
L-threonine-O-3-phosphate decarboxylase Inferred from experiment : cobD ( Salmonella enterica enterica serovar Typhimurium )

In Pathway: aminopropanol phosphate biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: threonine-phosphate decarboxylase

Enzyme Commission Synonyms: L-threonine-O-3-phosphate decarboxylase, CobD, L-threonine-O-3-phosphate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.8418121 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme is unable to decarboxylate the D-isomer of threonine

Citations: [Warren02, Brushaber98, Cheong02]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R06530 , Rhea:11492

Relationship Links: BRENDA:EC:4.1.1.81 , ENZYME:EC:4.1.1.81 , IUBMB-ExplorEnz:EC:4.1.1.81


References

Brushaber98: Brushaber KR, O'Toole GA, Escalante-Semerena JC (1998). "CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2." J Biol Chem 273(5);2684-91. PMID: 9446573

Cheong02: Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I (2002). "Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica." Biochemistry 41(15);4798-808. PMID: 11939774

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Warren02: Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14B.