MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Pseudomonas denitrificans: threonine-phosphate decarboxylase: cobC
Salmonella enterica enterica serovar Typhimurium: L-threonine-O-3-phosphate decarboxylaseInferred from experiment: cobD

In Pathway: aminopropanol phosphate biosynthesis I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: threonine-phosphate decarboxylase

Enzyme Commission Synonyms: L-threonine-O-3-phosphate decarboxylase, CobD, L-threonine-O-3-phosphate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.8418121Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme is unable to decarboxylate the D-isomer of threonine

Citations: [Warren02, Brushaber98, Cheong02]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R06530, Rhea:11492

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Brushaber98: Brushaber KR, O'Toole GA, Escalante-Semerena JC (1998). "CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2." J Biol Chem 273(5);2684-91. PMID: 9446573

Cheong02: Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I (2002). "Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica." Biochemistry 41(15);4798-808. PMID: 11939774

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Warren02: Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)." Nat Prod Rep 19(4);390-412. PMID: 12195810

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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