Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Bacillus subtilis spizizenii ATCC 6633: 3-phosphonopyruvate decarboxylaseInferred from experimentInferred by computational analysis: rhiF, rhiE
Streptomyces luridus: phosphonopyruvate decarboxylaseInferred from experiment: dhpF
Streptomyces viridochromogenes: phosphonopyruvate decarboxylaseInferred from experiment: ppd
Streptomyces wedmorensis: phosphonopyruvate decarboxylaseInferred from experiment: fom2
Tetrahymena pyriformis: phosphonopyruvate decarboxylaseInferred from experiment

In Pathway: dehydrophos biosynthesis, 2-aminoethylphosphonate biosynthesis, rhizocticin A and B biosynthesis, fosfomycin biosynthesis, phosphinothricin tripeptide biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphonopyruvate decarboxylase

Enzyme Commission Synonyms: 3-phosphonopyruvate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -2.8417358Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Catalyzes a step in the biosynthetic pathway of 2 aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Activated by the divalent cations Mg(2+), Ca(2+) and Mn(2+). Pyruvate and sulfopyruvate can also act as substrates, but more slowly.

Citations: [Nakashita97, Seidel94, Zhang03e]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04053, Rhea:20768

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakashita97: Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H (1997). "Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate." J Antibiot (Tokyo) 50(3);212-9. PMID: 9127192

Seidel94: Seidel HM, Knowles JR (1994). "Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site." Biochemistry 33(18);5641-6. PMID: 8180189

Zhang03e: Zhang G, Dai J, Lu Z, Dunaway-Mariano D (2003). "The phosphonopyruvate decarboxylase from Bacteroides fragilis." J Biol Chem 278(42);41302-8. PMID: 12904299

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Feb 9, 2016, biocyc11.