Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.1.82

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.82

Enzymes and Genes:
3-phosphonopyruvate decarboxylase Inferred from experiment Inferred by computational analysis : rhiF , rhiE ( Bacillus subtilis spizizenii ATCC 6633 )
phosphonopyruvate decarboxylase Inferred from experiment ( Tetrahymena pyriformis )
phosphonopyruvate decarboxylase Inferred from experiment : dhpF ( Streptomyces luridus )
phosphonopyruvate decarboxylase Inferred from experiment : ppd ( Streptomyces viridochromogenes )
phosphonopyruvate decarboxylase Inferred from experiment : fom2 ( Streptomyces wedmorensis )

In Pathway: fosfomycin biosynthesis , phosphinothricin tripeptide biosynthesis , dehydrophos biosynthesis , 2-aminoethylphosphonate biosynthesis , rhizocticin A and B biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphonopyruvate decarboxylase

Enzyme Commission Synonyms: 3-phosphonopyruvate carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -2.8417358 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Catalyzes a step in the biosynthetic pathway of 2 aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Activated by the divalent cations Mg(2+), Ca(2+) and Mn(2+). Pyruvate and sulfopyruvate can also act as substrates, but more slowly.

Citations: [Nakashita97, Seidel94, Zhang03l]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04053 , Rhea:20768

Relationship Links: BRENDA:EC:4.1.1.82 , ENZYME:EC:4.1.1.82 , IUBMB-ExplorEnz:EC:4.1.1.82


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakashita97: Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H (1997). "Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate." J Antibiot (Tokyo) 50(3);212-9. PMID: 9127192

Seidel94: Seidel HM, Knowles JR (1994). "Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site." Biochemistry 33(18);5641-6. PMID: 8180189

Zhang03l: Zhang G, Dai J, Lu Z, Dunaway-Mariano D (2003). "The phosphonopyruvate decarboxylase from Bacteroides fragilis." J Biol Chem 278(42);41302-8. PMID: 12904299


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 20, 2014, BIOCYC14A.