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MetaCyc Reaction: 4.2.2.11

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 4.2.2.11

Enzymes and Genes:

Sphingomonas sp. A1: alginate lyase IIInferred from experiment: aly

In Pathway: alginate degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: poly(α-L-guluronate) lyase

Enzyme Commission Synonyms: alginase II, guluronate lyase, L-guluronan lyase, L-guluronate lyase, poly-α-L-guluronate lyase, polyguluronate-specific alginate lyase, poly(α-L-1,4-guluronide) exo-lyase

Enzyme Commission Summary:
The enzyme catalyses the degradation of alginate by a β-elimination reaction. It cleaves the (1→4) bond between α-L-guluronate and either α-L-guluronate or β-D-mannuronate, generating oligosaccharides with 4-deoxy-α-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and α-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. cf. EC 4.2.2.3, poly(β-D-mannuronate) lyase.

Citations: [Boyd77, Davidson76]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:4.2.2.11, ENZYME:EC:4.2.2.11, IUBMB-ExplorEnz:EC:4.2.2.11


References

Boyd77: Boyd J, Turvey JR (1977). "Isolation of poly-alpha-L-guluronate lyase from Klebsiella aerogenes." Carbohydr Res 57;163-71. PMID: 332364

Davidson76: Davidson IW, Sutherland IW, Lawson CJ (1976). "Purification and properties of an alginate lyase from a marine bacterium." Biochem J 159(3);707-13. PMID: 1008828


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc13.