MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Sphingomonas sp. A1: alginate lyase IIInferred from experiment: aly

In Pathway: alginate degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: poly(α-L-guluronate) lyase

Enzyme Commission Synonyms: alginase II, guluronate lyase, L-guluronan lyase, L-guluronate lyase, poly-α-L-guluronate lyase, polyguluronate-specific alginate lyase, poly(α-L-1,4-guluronide) exo-lyase

Enzyme Commission Summary:
The enzyme catalyses the degradation of alginate by a β-elimination reaction. It cleaves the (1→4) bond between α-L-guluronate and either α-L-guluronate or β-D-mannuronate, generating oligosaccharides with 4-deoxy-α-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and α-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. cf. EC, poly(β-D-mannuronate) lyase.

Citations: [Boyd77, Davidson76]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Boyd77: Boyd J, Turvey JR (1977). "Isolation of poly-alpha-L-guluronate lyase from Klebsiella aerogenes." Carbohydr Res 57;163-71. PMID: 332364

Davidson76: Davidson IW, Sutherland IW, Lawson CJ (1976). "Purification and properties of an alginate lyase from a marine bacterium." Biochem J 159(3);707-13. PMID: 1008828

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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