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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Populus alba: isoprene synthaseInferred from experiment: IspS

In Pathway: isoprene biosynthesis I, isoprene biosynthesis II (engineered)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: isoprene synthase

Enzyme Commission Synonyms: ISPC, ISPS

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.299988Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Located in the chloroplast of isoprene-emitting plants, such as poplar and aspen, and may be activitated by light-dependent changes in chloroplast pH and Mg(2+) concentration.

Citations: [Silver91, Wildermuth96, Miller01, Sivy02, Sasaki05, Schnitzler05, Silver95]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R08199, Rhea:13369

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miller01: Miller B, Oschinski C, Zimmer W (2001). "First isolation of an isoprene synthase gene from poplar and successful expression of the gene in Escherichia coli." Planta 213(3);483-7. PMID: 11506373

Sasaki05: Sasaki K, Ohara K, Yazaki K (2005). "Gene expression and characterization of isoprene synthase from Populus alba." FEBS Lett 579(11);2514-8. PMID: 15848197

Schnitzler05: Schnitzler JP, Zimmer I, Bachl A, Arend M, Fromm J, Fischbach RJ (2005). "Biochemical properties of isoprene synthase in poplar (Populus x canescens)." Planta 222(5);777-86. PMID: 16052321

Silver91: Silver GM, Fall R (1991). "Enzymatic synthesis of isoprene from dimethylallyl diphosphate in aspen leaf extracts." Plant Physiol 97(4);1588-91. PMID: 16668590

Silver95: Silver GM, Fall R (1995). "Characterization of aspen isoprene synthase, an enzyme responsible for leaf isoprene emission to the atmosphere." J Biol Chem 270(22);13010-6. PMID: 7768893

Sivy02: Sivy TL, Shirk MC, Fall R (2002). "Isoprene synthase activity parallels fluctuations of isoprene release during growth of Bacillus subtilis." Biochem Biophys Res Commun 294(1);71-5. PMID: 12054742

Wildermuth96: Wildermuth MC, Fall R (1996). "Light-Dependent Isoprene Emission (Characterization of a Thylakoid-Bound Isoprene Synthase in Salix discolor Chloroplasts)." Plant Physiol 112(1);171-182. PMID: 12226383

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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