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MetaCyc Reaction: 2.7.2.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.2.8

Enzymes and Genes:

Bacillus subtilis : acetylglutamate kinase Inferred from experiment : argB
Escherichia coli K-12 substr. MG1655 : acetylglutamate kinase Inferred from experiment : argB
Saccharomyces cerevisiae : acetylglutamate kinase : ARG5,6

In Pathway: L-ornithine biosynthesis , L-arginine biosynthesis II (acetyl cycle) , L-arginine biosynthesis III (via N-acetyl-L-citrulline)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetylglutamate kinase

Enzyme Commission Synonyms: N-acetylglutamate 5-phosphotransferase, acetylglutamate phosphokinase, N-acetylglutamate phosphokinase, N-acetylglutamate kinase, N-acetylglutamic 5-phosphotransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.9141846 Inferred by computational analysis [Latendresse13]

Citations: [Baich62, Farago67]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02649 , Rhea:14629

Relationship Links: BRENDA:EC:2.7.2.8 , ENZYME:EC:2.7.2.8 , IUBMB-ExplorEnz:EC:2.7.2.8 , UniProt:RELATED-TO:O50147 , UniProt:RELATED-TO:P0A6C8 , UniProt:RELATED-TO:P31318 , UniProt:RELATED-TO:P54898 , UniProt:RELATED-TO:P69365 , UniProt:RELATED-TO:P69366 , UniProt:RELATED-TO:P73326 , UniProt:RELATED-TO:Q9CHD2 , UniProt:RELATED-TO:Q9JUK2 , UniProt:RELATED-TO:Q9PIR8 , UniProt:RELATED-TO:Q01217 , UniProt:RELATED-TO:Q07905 , UniProt:RELATED-TO:Q60382


References

Baich62: Baich A, Vogel HJ (1962). "N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli." Biochem Biophys Res Commun 7;491-6. PMID: 13863980

Farago67: Farago A, Denes G (1967). "Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. II. Purification and properties of N-acetylglutamate 5-phosphotransferase, the allosteric enzyme of the pathway." Biochim Biophys Acta 136(1);6-18. PMID: 6040410

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, BIOCYC14B.