Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: NADPH-dependent aldehyde reductaseInferred from experiment: yqhD
NADP+-dependent aldehyde reductaseInferred from experiment: ybbO
aldehyde reductase, NADPH-dependentInferred from experiment: ahr
aldehyde reductase, NADPH-dependentInferred from experiment: yahK

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Instance reactions:
(6E)-8-oxogeraniol + NADP+ ↔ (6E)-8-oxogeranial + NADPH + H+ (1.1.1.-)

(2E,6E)-farnesol + NADP+ ↔ (2E,6E)-farnesal + NADPH + H+ (

(R)-propane-1,2-diol + NADP+ ← (R)-lactaldehyde + NADPH + H+ (1.1.1.-)

(S)-propane-1,2-diol + NADP+ ← (S)-lactaldehyde + NADPH + H+ (1.1.1.-)

(S)-propane-1,2-diol + NADP+ = (S)-lactaldehyde + NADPH + H+ (

n-butanol + NADP+ ↔ butanal + NADPH + H+ (1.1.1.-)

ethanol + NADP+ = acetaldehyde + NADPH + H+ (

(E)-2-pentenol + NADP+ ← (E)-2-pentenal + NADPH + H+ (1.1.1.-)

xylitol + NADP+ ↔ D-xylopyranose + NADPH + H+ (1.1.1.-)

L-arabitol + NADP+ ↔ L-arabinopyranose + NADPH + H+ (

glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ (

glycerol + NADP+ ← L-glyceraldehyde + NADPH + H+ (

(E)-2-hexenol + NADP+ ← (E)-2-hexenal + NADPH + H+ (1.1.1.-)

galactitol + NADP+ ↔ D-galactopyranose + NADPH + H+ (

geraniol + NADP+ → geranial + NADPH + H+ (

(6E)-8-hydroxygeranial + NADP+ → (6E)-8-oxogeranial + NADPH + H+ (1.1.1.-)

Enzyme Commission Primary Name: alcohol dehydrogenase (NADP+)

Enzyme Commission Synonyms: aldehyde reductase (NADPH2), NADP-alcohol dehydrogenase, NADP+-aldehyde reductase, NADP+-dependent aldehyde reductase, NADPH-aldehyde reductase, NADPH-dependent aldehyde reductase, nonspecific succinic semialdehyde reductase, ALR 1, low-Km aldehyde reductase, high-Km aldehyde reductase, alcohol dehydrogenase (NADP)

Taxonomic Range: Bacteria , Fungi, Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 23.45575Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC, glucuronate reductase, EC, mevaldate reductase (NADPH) and EC, lactaldehyde reductase (NADPH). Re-specific with respect to NADPH.

Citations: [Bosron72, Tabakoff70, Murata85, Chen03d]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R07328, Rhea:15940

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O06007, UniProt:RELATED-TO:P0A4X0, UniProt:RELATED-TO:P0A4X1, UniProt:RELATED-TO:P14550, UniProt:RELATED-TO:P14941, UniProt:RELATED-TO:P25377, UniProt:RELATED-TO:P35630, UniProt:RELATED-TO:P75214, UniProt:RELATED-TO:P75691, UniProt:RELATED-TO:P77990, UniProt:RELATED-TO:Q7M0Z4, UniProt:RELATED-TO:Q7M543, UniProt:RELATED-TO:Q7M544, UniProt:RELATED-TO:Q9PMC1, UniProt:RELATED-TO:Q04894

Revised 06-Sep-2012 by Caspi R, SRI International


Bosron72: Bosron WF, Prairie RL (1972). "Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex." J Biol Chem 247(14);4480-5. PMID: 4402936

Chen03d: Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH (2003). "Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae." Yeast 20(6);545-54. PMID: 12722185

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murata85: Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A (1985). "Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae." Eur J Biochem 151(3);631-6. PMID: 3896793

Tabakoff70: Tabakoff B, Erwin VG (1970). "Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain." J Biol Chem 245(12);3263-8. PMID: 4393513

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Feb 11, 2016, biocyc12.