Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.1.1.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.2

Enzymes and Genes:
NADPH-dependent aldehyde reductase Inferred from experiment : yqhD ( Escherichia coli K-12 substr. MG1655 )
aldehyde reductase, NADPH-dependent Inferred from experiment : ahr ( Escherichia coli K-12 substr. MG1655 )
NADP+-dependent aldehyde reductase Inferred from experiment : ybbO ( Escherichia coli K-12 substr. MG1655 )
aldehyde reductase, NADPH-dependent Inferred from experiment : yahK ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Marked as unbalanced.

Instance reactions:
n-butanol + NADP+ ↔ butanal + NADPH + H+ (1.1.1.-)

trans-2-pentenol + NADP+trans-2-pentenal + NADPH + H+ (1.1.1.-)

glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ (1.1.1.72/1.1.1.372)

glycerol + NADP+ ← L-glyceraldehyde + NADPH + H+ (1.1.1.372)

ethanol + NADP+ = acetaldehyde + NADPH + H+ (1.1.1.2)

(2E,6E)-farnesol + NADP+ ↔ (2E,6E)-farnesal + NADPH + H+ (1.1.1.216)

galactitol + NADP+ ↔ β-D-galactose + NADPH + H+ (1.1.1.21)

(R)-propane-1,2-diol + NADP+ ← (R)-lactaldehyde + NADPH + H+ (1.1.1.-)

(S)-propane-1,2-diol + NADP+ ← (S)-lactaldehyde + NADPH + H+ (1.1.1.-)

(S)-propane-1,2-diol + NADP+ = (S)-lactaldehyde + NADPH + H+ (1.1.1.55)

trans-2-hexenol + NADP+ ← trans-2-hexenal + NADPH + H+ (1.1.1.-)

(6E)-8-oxogeraniol + NADP+ ↔ (6E)-8-oxogeranial + NADPH + H+ (1.1.1.-)

(6E)-8-hydroxygeranial + NADP+ → (6E)-8-oxogeranial + NADPH + H+ (1.1.1.-)

geraniol + NADP+ → geranial + NADPH + H+ (1.1.1.183)

Enzyme Commission Primary Name: alcohol dehydrogenase (NADP+)

Enzyme Commission Synonyms: aldehyde reductase (NADPH2), NADP-alcohol dehydrogenase, NADP+-aldehyde reductase, NADP+-dependent aldehyde reductase, NADPH-aldehyde reductase, NADPH-dependent aldehyde reductase, nonspecific succinic semialdehyde reductase, ALR 1, low-Km aldehyde reductase, high-Km aldehyde reductase, alcohol dehydrogenase (NADP)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 23.45575 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19, glucuronate reductase, EC 1.1.1.33, mevaldate reductase (NADPH) and EC 1.1.1.55, lactaldehyde reductase (NADPH). Re-specific with respect to NADPH.

Citations: [Bosron72, Tabakoff70, Murata85, Chen03a]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R07328 , Rhea:15940

Relationship Links: BRENDA:EC:1.1.1.2 , ENZYME:EC:1.1.1.2 , IUBMB-ExplorEnz:EC:1.1.1.2 , UniProt:RELATED-TO:O06007 , UniProt:RELATED-TO:P0A4X0 , UniProt:RELATED-TO:P0A4X1 , UniProt:RELATED-TO:P14550 , UniProt:RELATED-TO:P14941 , UniProt:RELATED-TO:P25377 , UniProt:RELATED-TO:P35630 , UniProt:RELATED-TO:P75214 , UniProt:RELATED-TO:P75691 , UniProt:RELATED-TO:P77990 , UniProt:RELATED-TO:Q7M0Z4 , UniProt:RELATED-TO:Q7M543 , UniProt:RELATED-TO:Q7M544 , UniProt:RELATED-TO:Q9PMC1 , UniProt:RELATED-TO:Q04894

Credits:
Revised 06-Sep-2012 by Caspi R , SRI International


References

Bosron72: Bosron WF, Prairie RL (1972). "Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex." J Biol Chem 247(14);4480-5. PMID: 4402936

Chen03a: Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH (2003). "Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae." Yeast 20(6);545-54. PMID: 12722185

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Murata85: Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A (1985). "Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae." Eur J Biochem 151(3);631-6. PMID: 3896793

Tabakoff70: Tabakoff B, Erwin VG (1970). "Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain." J Biol Chem 245(12);3263-8. PMID: 4393513


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC14B.