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MetaCyc Reaction: 1.2.1.5

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.2.1.5

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
methylglyoxal + NADP+ + H2O → pyruvate + NADPH + 2 H+ (1.2.1.49)

methylglyoxal + NAD+ + H2O → pyruvate + NADH + 2 H+ (1.2.1.23)

fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (1.2.1.69)

(2E,6E)-farnesal + NAD+ + H2O → (2E,6E)-farnesoate + NADH + 2 H+ (1.2.1.94)

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + 2 H+ (1.2.1.89)

(R)-lactaldehyde + NAD+ + H2O → (R)-lactate + NADH + 2 H+ (no EC#)

dodecanal + NAD+ + H2O = laurate + NADH + 2 H+ (1.2.1.3)

decanal + NAD+ + H2O = decanoate + NADH + 2 H+ (1.2.1.3)

salicylaldehyde + NAD+ + H2O → salicylate + NADH + 2 H+ (1.2.1.65)

acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (1.2.1.3)

acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (1.2.1.4)

4-methylbenzaldehyde + NAD+ + H2O → 4-toluenecarboxylate + NADH + 2 H+ (no EC#)

formaldehyde + NAD+ + H2O → formate + NADH + 2 H+ (1.2.1.46)

octanal + NAD+ + H2O → octanoate + NADH + 2 H+ (1.2.1.3)

all-trans-retinal + NAD+ + H2O = all-trans-retinoate + NADH + 2 H+ (1.2.1.36)

benzaldehyde + NADP+ + H2O → benzoate + NADPH + 2 H+ (1.2.1.7)

benzaldehyde + NAD+ + H2O ↔ benzoate + NADH + 2 H+ (1.2.1.28)

phytenal + NAD+ + H2O → phytenate + NADH + 2 H+ (1.2.1.3)

a fatty aldehyde + NAD+ + H2O → a fatty acid + NADH + 2 H+ (1.2.1.3)

a 2-methyl branched 2,3,4-saturated fatty aldehyde + NAD+ + H2O → a 2-methyl branched 2,3,4-saturated fatty acid + NADH + 2 H+ (1.2.1.3)

a long-chain aldehyde + NAD+ + H2O = a long-chain fatty acid + NADH + 2 H+ (1.2.1.48)

an odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O → an odd numbered straight chain 2,3,4-saturated fatty acid + NADH + 2 H+ (1.2.1.3)

Enzyme Commission Primary Name: aldehyde dehydrogenase [NAD(P)+]

Enzyme Commission Synonyms: ALDH

Taxonomic Range: Fungi, Bacteria , Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105347Inferred by computational analysis [Latendresse13]

Citations: [Black51, King56, Steinman67, Tanenbaum56]

Relationship Links: BRENDA:EC:1.2.1.5, ENZYME:EC:1.2.1.5, IUBMB-ExplorEnz:EC:1.2.1.5, UniProt:RELATED-TO:P30838, UniProt:RELATED-TO:P47771, UniProt:RELATED-TO:P51647

Credits:
Revised 16-Sep-2011 by Caspi R, SRI International


References

Black51: Black S (1951). "Yeast aldehyde dehydrogenase." Arch Biochem Biophys 34(1);86-97. PMID: 14904038

King56: King TE, Cheldelin VH (1956). "Oxidation of acetaldehyde by Acetobacter suboxydans." J Biol Chem 220(1);177-91. PMID: 13319337

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Steinman67: Steinman CR, Jakoby WB (1967). "Yeast aldehyde dehydrogenase. I. Purification and crystallization." J Biol Chem 242(21);5019-23. PMID: 4293780

Tanenbaum56: Tanenbaum, S.W. (1956). "The metabolism of Acetobacter peroxidans. I. Oxidative enzymes." Biochim Biophys Acta 21(2);335-42. PMID: 13363916


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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