Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.2.1.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.5

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (1.2.1.69)

benzaldehyde + NADP+ + H2O → benzoate + NADPH + 2 H+ (1.2.1.7)

benzaldehyde + NAD+ + H2O ↔ benzoate + NADH + 2 H+ (1.2.1.28)

4-methylbenzaldehyde + NAD+ + H2O → 4-toluenecarboxylate + NADH + 2 H+ (no EC#)

all-trans-retinal + NAD+ + H2O = all-trans-retinoate + NADH + 2 H+ (1.2.1.36)

acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (1.2.1.3)

acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (1.2.1.4)

octanal + NAD+ + H2O → octanoate + NADH + 2 H+ (1.2.1.3)

phytenal + NAD+ + H2O → phytenate + NADH + 2 H+ (1.2.1.3)

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + 2 H+ (1.2.1.89)

(2E,6E)-farnesal + NAD+ + H2O → (2-trans-6-trans)-farnesoate + NADH + 2 H+ (1.2.1.3)

salicylaldehyde + NAD+ + H2O → salicylate + NADH + 2 H+ (1.2.1.65)

(R)-lactaldehyde + NAD+ + H2O → (R)-lactate + NADH + 2 H+ (no EC#)

(S)-lactaldehyde + NADP+ + H2O → (S)-lactate + NADPH + 2 H+ (1.2.1.-)

(S)-lactaldehyde + NAD+ + H2O → (S)-lactate + NADH + 2 H+ (1.2.1.22)

methylglyoxal + NADP+ + H2O → pyruvate + NADPH + 2 H+ (1.2.1.49)

methylglyoxal + NAD+ + H2O → pyruvate + NADH + 2 H+ (1.2.1.23)

Enzyme Commission Primary Name: aldehyde dehydrogenase [NAD(P)+]

Enzyme Commission Synonyms: ALDH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105347 Inferred by computational analysis [Latendresse13]

Citations: [Black51, King56, Steinman67, Tanenbaum56]

Relationship Links: BRENDA:EC:1.2.1.5 , ENZYME:EC:1.2.1.5 , IUBMB-ExplorEnz:EC:1.2.1.5 , UniProt:RELATED-TO:P30838 , UniProt:RELATED-TO:P47771 , UniProt:RELATED-TO:P51647

Credits:
Revised 16-Sep-2011 by Caspi R , SRI International


References

Black51: Black S (1951). "Yeast aldehyde dehydrogenase." Arch Biochem Biophys 34(1);86-97. PMID: 14904038

King56: King TE, Cheldelin VH (1956). "Oxidation of acetaldehyde by Acetobacter suboxydans." J Biol Chem 220(1);177-91. PMID: 13319337

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Steinman67: Steinman CR, Jakoby WB (1967). "Yeast aldehyde dehydrogenase. I. Purification and crystallization." J Biol Chem 242(21);5019-23. PMID: 4293780

Tanenbaum56: Tanenbaum, S.W. (1956). "The metabolism of Acetobacter peroxidans. I. Oxidative enzymes." Biochim Biophys Acta 21(2);335-42. PMID: 13363916


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc14.