Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.2.1.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.5

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (1.2.1.69)

benzaldehyde + NADP+ + H2O → benzoate + NADPH + 2 H+ (1.2.1.7)

benzaldehyde + NAD+ + H2O ↔ benzoate + NADH + 2 H+ (1.2.1.28)

4-methylbenzaldehyde + NAD+ + H2O → 4-toluenecarboxylate + NADH + 2 H+ (no EC#)

all-trans-retinal + NAD+ + H2O = all-trans-retinoate + NADH + 2 H+ (1.2.1.36)

acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (1.2.1.3)

acetaldehyde + NADP+ + H2O → acetate + NADPH + 2 H+ (1.2.1.4)

octanal + NAD+ + H2O → octanoate + NADH + 2 H+ (1.2.1.3)

phytenal + NAD+ + H2O → phytenate + NADH + 2 H+ (1.2.1.3)

D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + 2 H+ (1.2.1.89)

(2E,6E)-farnesal + NAD+ + H2O → (2-trans-6-trans)-farnesoate + NADH + 2 H+ (1.2.1.3)

salicylaldehyde + NAD+ + H2O → salicylate + NADH + 2 H+ (1.2.1.65)

(R)-lactaldehyde + NAD+ + H2O → (R)-lactate + NADH + 2 H+ (no EC#)

(S)-lactaldehyde + NADP+ + H2O → (S)-lactate + NADPH + 2 H+ (1.2.1.-)

(S)-lactaldehyde + NAD+ + H2O → (S)-lactate + NADH + 2 H+ (1.2.1.22)

methylglyoxal + NADP+ + H2O → pyruvate + NADPH + 2 H+ (1.2.1.49)

methylglyoxal + NAD+ + H2O → pyruvate + NADH + 2 H+ (1.2.1.23)

Enzyme Commission Primary Name: aldehyde dehydrogenase [NAD(P)+]

Enzyme Commission Synonyms: ALDH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.105347 Inferred by computational analysis [Latendresse13]

Citations: [Black51, King56, Steinman67, Tanenbaum56]

Relationship Links: BRENDA:EC:1.2.1.5 , ENZYME:EC:1.2.1.5 , IUBMB-ExplorEnz:EC:1.2.1.5 , UniProt:RELATED-TO:P30838 , UniProt:RELATED-TO:P47771 , UniProt:RELATED-TO:P51647

Credits:
Revised 16-Sep-2011 by Caspi R , SRI International


References

Black51: Black S (1951). "Yeast aldehyde dehydrogenase." Arch Biochem Biophys 34(1);86-97. PMID: 14904038

King56: King TE, Cheldelin VH (1956). "Oxidation of acetaldehyde by Acetobacter suboxydans." J Biol Chem 220(1);177-91. PMID: 13319337

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Steinman67: Steinman CR, Jakoby WB (1967). "Yeast aldehyde dehydrogenase. I. Purification and crystallization." J Biol Chem 242(21);5019-23. PMID: 4293780

Tanenbaum56: Tanenbaum, S.W. (1956). "The metabolism of Acetobacter peroxidans. I. Oxidative enzymes." Biochim Biophys Acta 21(2);335-42. PMID: 13363916


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14B.