twitter

MetaCyc Reaction: 4.1.1.28

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.28

Enzymes and Genes:
tryptophan decarboxylase Inferred from experiment : tdc2 ( Camptotheca acuminata )
tryptophan decarboxylase Inferred from experiment : tdc1 ( Camptotheca acuminata )
tryptophan decarboxylase Inferred from experiment : tdc ( Ophiorrhiza pumila )
aromatic L-amino acid decarboxylase Inferred from experiment : DDC ( Sus scrofa )
tryptophan decarboxylase Inferred from experiment : TDC ( Catharanthus roseus )
aromatic L-amino acid decarboxylase Inferred from experiment : DDC ( Homo sapiens )
L-tryptophan decarboxylase Inferred from experiment ( Micrococcus percitreus )
tryptophan decarboxylase Inferred from experiment ( Bacillus sp. No. 230 )

In Pathway: L-tryptophan degradation VI (via tryptamine) , hydroxycinnamic acid serotonin amides biosynthesis , beta-carboline biosynthesis , L-tryptophan degradation X (mammalian, via tryptamine) , indole-3-acetate biosynthesis II , camptothecin biosynthesis , secologanin and strictosidine biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number, which can be found here and here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aromatic-L-amino-acid decarboxylase

Enzyme Commission Synonyms: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.549004 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan [Christenson72, Lovenberg et al., 1962, WEISSBACH57].

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00685 , Rhea:30339

Relationship Links: BRENDA:EC:4.1.1.28 , ENZYME:EC:4.1.1.28 , IUBMB-ExplorEnz:EC:4.1.1.28 , UniProt:RELATED-TO:O82414 , UniProt:RELATED-TO:P05031 , UniProt:RELATED-TO:P14173 , UniProt:RELATED-TO:P17770 , UniProt:RELATED-TO:P20711 , UniProt:RELATED-TO:P22781 , UniProt:RELATED-TO:P27718 , UniProt:RELATED-TO:P34751 , UniProt:RELATED-TO:P54770 , UniProt:RELATED-TO:P54771


References

Christenson72: Christenson JG, Dairman W, Udenfriend S (1972). "On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)." Proc Natl Acad Sci U S A 69(2);343-7. PMID: 4536745

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lovenberg et al., 1962: Lovenberg, W, Weissbach, H, Udenfriend, S (1962). "Aromatic L-amino acid decarboxylase." J Biol Chem 237;89-93. PMID: 14466899

WEISSBACH57: WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S (1957). "Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation." J Biol Chem 227(2);617-24. PMID: 13462983


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Mar 27, 2015, biocyc14.