Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.1.28

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.28

Enzymes and Genes:
tryptophan decarboxylase Inferred from experiment : tdc2 ( Camptotheca acuminata )
tryptophan decarboxylase Inferred from experiment : tdc1 ( Camptotheca acuminata )
tryptophan decarboxylase Inferred from experiment : tdc ( Ophiorrhiza pumila )
aromatic L-amino acid decarboxylase Inferred from experiment : DDC ( Sus scrofa )
tryptophan decarboxylase Inferred from experiment : TDC ( Catharanthus roseus )
aromatic L-amino acid decarboxylase Inferred from experiment : DDC ( Homo sapiens )
L-tryptophan decarboxylase Inferred from experiment ( Micrococcus percitreus )
tryptophan decarboxylase Inferred from experiment ( Bacillus sp. No. 230 )

In Pathway: tryptophan degradation VI (via tryptamine) , hydroxycinnamic acid serotonin amides biosynthesis , beta-carboline biosynthesis , tryptophan degradation X (mammalian, via tryptamine) , indole-3-acetate biosynthesis II , camptothecin biosynthesis , secologanin and strictosidine biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number, which can be found here and here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aromatic-L-amino-acid decarboxylase

Enzyme Commission Synonyms: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.549004 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan [Christenson72, LOVENBERG62, WEISSBACH57].

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00685 , Rhea:30339

Relationship Links: BRENDA:EC:4.1.1.28 , ENZYME:EC:4.1.1.28 , IUBMB-ExplorEnz:EC:4.1.1.28 , UniProt:RELATED-TO:O82414 , UniProt:RELATED-TO:P05031 , UniProt:RELATED-TO:P14173 , UniProt:RELATED-TO:P17770 , UniProt:RELATED-TO:P20711 , UniProt:RELATED-TO:P22781 , UniProt:RELATED-TO:P27718 , UniProt:RELATED-TO:P34751 , UniProt:RELATED-TO:P54770 , UniProt:RELATED-TO:P54771


References

Christenson72: Christenson JG, Dairman W, Udenfriend S (1972). "On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)." Proc Natl Acad Sci U S A 69(2);343-7. PMID: 4536745

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

LOVENBERG62: Lovenberg, W, Weissbach, H, Udenfriend, S (1962). "Aromatic L-amino acid decarboxylase." J Biol Chem 237;89-93. PMID: 14466899

WEISSBACH57: WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S (1957). "Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation." J Biol Chem 227(2);617-24. PMID: 13462983


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Dec 17, 2014, BIOCYC14B.