MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Bacillus sp. No. 230: tryptophan decarboxylaseInferred from experiment
Camptotheca acuminata: tryptophan decarboxylaseInferred from experiment: tdc1
tryptophan decarboxylaseInferred from experiment: tdc2
Catharanthus roseus: tryptophan decarboxylaseInferred from experiment: TDC
Homo sapiens: aromatic L-amino acid decarboxylaseInferred from experiment: DDC
Micrococcus percitreus : L-tryptophan decarboxylaseInferred from experiment
Ophiorrhiza pumila: tryptophan decarboxylaseInferred from experiment: tdc
Sus scrofa: aromatic L-amino acid decarboxylaseInferred from experiment: DDC

In Pathway: L-tryptophan degradation VI (via tryptamine), hydroxycinnamic acid serotonin amides biosynthesis, beta-carboline biosynthesis, L-tryptophan degradation X (mammalian, via tryptamine), indole-3-acetate biosynthesis II, camptothecin biosynthesis, secologanin and strictosidine biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC number, which can be found here and here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: aromatic-L-amino-acid decarboxylase

Enzyme Commission Synonyms: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)

Standard Gibbs Free Energy (ΔrG): -22.549004 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.

Citations: [Weissbach57, Lovenberg62, Christenson72]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Unification Links: KEGG:R00685, Rhea:30339

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O82414, UniProt:RELATED-TO:P05031, UniProt:RELATED-TO:P14173, UniProt:RELATED-TO:P17770, UniProt:RELATED-TO:P20711, UniProt:RELATED-TO:P22781, UniProt:RELATED-TO:P27718, UniProt:RELATED-TO:P34751, UniProt:RELATED-TO:P54770, UniProt:RELATED-TO:P54771


Christenson72: Christenson JG, Dairman W, Udenfriend S (1972). "On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine)." Proc Natl Acad Sci U S A 69(2);343-7. PMID: 4536745

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lovenberg62: Lovenberg, W, Weissbach, H, Udenfriend, S (1962). "Aromatic L-amino acid decarboxylase." J Biol Chem 237;89-93. PMID: 14466899

Weissbach57: Weissbach H, Bogdanski DF, Redfield BG, Udenfriend S (1957). "Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation." J Biol Chem 227(2);617-24. PMID: 13462983

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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