Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.5.1.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.1.9

Enzymes and Genes:
arylformamidase Inferred from experiment : Afmid ( Mus musculus )
arylformamidase Inferred by computational analysis : BNA3 ( Saccharomyces cerevisiae )
kynurenine formamidase Inferred from experiment : kynB ( Cupriavidus metallidurans CH34 )
kynurenine formamidase II Inferred from experiment ( Streptomyces parvulus )
kynurenine formamidase I Inferred from experiment ( Streptomyces parvulus )

In Pathway: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde , tryptophan degradation I (via anthranilate) , tryptophan degradation XI (mammalian, via kynurenine)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: arylformamidase

Enzyme Commission Synonyms: kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, formamidase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.1171227 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts on other aromatic formylamines.

Citations: [HAYAISHI51, JAKOBY54, MEHLER50]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01959 , Rhea:13009

Relationship Links: BRENDA:EC:3.5.1.9 , ENZYME:EC:3.5.1.9 , IUBMB-ExplorEnz:EC:3.5.1.9


References

HAYAISHI51: HAYAISHI O, STANIER RY (1951). "The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway." J Bacteriol 62(6);691-709. PMID: 14907621

JAKOBY54: JAKOBY WB (1954). "Kynurenine formamidase from Neurospora." J Biol Chem 207(2);657-63. PMID: 13163050

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MEHLER50: MEHLER AH, KNOX WE (1950). "The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine." J Biol Chem 187(1);431-8. PMID: 14794728


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, BIOCYC13B.