MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Cupriavidus metallidurans CH34: kynurenine formamidaseInferred from experiment: kynB
Mus musculus: arylformamidaseInferred from experiment: Afmid
Saccharomyces cerevisiae: arylformamidaseInferred by computational analysis: BNA3
Streptomyces anulatus: arylformamidaseInferred from experiment: acmF
Streptomyces parvulus: kynurenine formamidase IInferred from experiment
kynurenine formamidase IIInferred from experiment

In Pathway: L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde, L-tryptophan degradation I (via anthranilate), L-tryptophan degradation XI (mammalian, via kynurenine), 3-hydroxy-4-methyl-anthranilate biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: arylformamidase

Enzyme Commission Synonyms: kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, formamidase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.1171227Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts on other aromatic formylamines.

Citations: [Hayaishi51, Jakoby54, Mehler50]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01959, Rhea:13009

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Hayaishi51: Hayaishi O, Stanier RY (1951). "The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway." J Bacteriol 62(6);691-709. PMID: 14907621

Jakoby54: Jakoby WB (1954). "Kynurenine formamidase from Neurospora." J Biol Chem 207(2);657-63. PMID: 13163050

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mehler50: Mehler AH, Knox WE (1950). "The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine." J Biol Chem 187(1);431-8. PMID: 14794728

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Nov 27, 2015, biocyc12.