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MetaCyc Reaction: 3.5.1.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.1.9

Enzymes and Genes:

Cupriavidus metallidurans CH34 : kynurenine formamidase Inferred from experiment : kynB
Mus musculus : arylformamidase Inferred from experiment : Afmid
Saccharomyces cerevisiae : arylformamidase Inferred by computational analysis : BNA3
Streptomyces parvulus : kynurenine formamidase I Inferred from experiment
kynurenine formamidase II Inferred from experiment

In Pathway: L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde , L-tryptophan degradation I (via anthranilate) , L-tryptophan degradation XI (mammalian, via kynurenine)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: arylformamidase

Enzyme Commission Synonyms: kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, formamidase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.1171227 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts on other aromatic formylamines.

Citations: [HAYAISHI51, JAKOBY54, MEHLER50]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01959 , Rhea:13009

Relationship Links: BRENDA:EC:3.5.1.9 , ENZYME:EC:3.5.1.9 , IUBMB-ExplorEnz:EC:3.5.1.9


References

HAYAISHI51: HAYAISHI O, STANIER RY (1951). "The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway." J Bacteriol 62(6);691-709. PMID: 14907621

JAKOBY54: JAKOBY WB (1954). "Kynurenine formamidase from Neurospora." J Biol Chem 207(2);657-63. PMID: 13163050

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MEHLER50: MEHLER AH, KNOX WE (1950). "The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine." J Biol Chem 187(1);431-8. PMID: 14794728


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 31, 2015, biocyc12.