MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : biotin carboxylase Inferred from experiment : accC
Homo sapiens : acetyl-CoA carboxylase 1
acetyl-CoA carboxylase 2 : ACC2

In Pathway: biotin-carboxyl carrier protein assembly

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: biotin carboxylase

Enzyme Commission Synonyms: biotin carboxylase (component of acetyl CoA carboxylase)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 19.045227 Inferred by computational analysis [Latendresse13]

Citations: [Dimroth70]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R04385

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O04983 , UniProt:RELATED-TO:O23960 , UniProt:RELATED-TO:O52602 , UniProt:RELATED-TO:O67483 , UniProt:RELATED-TO:O81273 , UniProt:RELATED-TO:P24182 , UniProt:RELATED-TO:P43873 , UniProt:RELATED-TO:Q9CHF3 , UniProt:RELATED-TO:Q9JW07 , UniProt:RELATED-TO:Q9PN09 , UniProt:RELATED-TO:Q9R9I4 , UniProt:RELATED-TO:Q06862 , UniProt:RELATED-TO:Q39825 , UniProt:RELATED-TO:Q42777 , UniProt:RELATED-TO:Q58626


Dimroth70: Dimroth P, Guchhait RB, Stoll E, Lane MD (1970). "Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase." Proc Natl Acad Sci U S A 67(3);1353-60. PMID: 4922289

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 3, 2015, biocyc13.