Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 6.3.4.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 6.3.4.14

Enzymes and Genes:
biotin carboxylase Inferred from experiment : accC ( Escherichia coli K-12 substr. MG1655 )
acetyl-CoA carboxylase 2 : ACC2 ( Homo sapiens )
acetyl-CoA carboxylase 1 ( Homo sapiens )

In Pathway: biotin-carboxyl carrier protein assembly

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: biotin carboxylase

Enzyme Commission Synonyms: biotin carboxylase (component of acetyl CoA carboxylase)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 20.293518 Inferred by computational analysis [Latendresse13]

Citations: [Dimroth70]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04385

Relationship Links: BRENDA:EC:6.3.4.14 , ENZYME:EC:6.3.4.14 , IUBMB-ExplorEnz:EC:6.3.4.14 , UniProt:RELATED-TO:O04983 , UniProt:RELATED-TO:O23960 , UniProt:RELATED-TO:O52602 , UniProt:RELATED-TO:O67483 , UniProt:RELATED-TO:O81273 , UniProt:RELATED-TO:P24182 , UniProt:RELATED-TO:P43873 , UniProt:RELATED-TO:Q9CHF3 , UniProt:RELATED-TO:Q9JW07 , UniProt:RELATED-TO:Q9PN09 , UniProt:RELATED-TO:Q9R9I4 , UniProt:RELATED-TO:Q06862 , UniProt:RELATED-TO:Q39825 , UniProt:RELATED-TO:Q42777 , UniProt:RELATED-TO:Q58626


References

Dimroth70: Dimroth P, Guchhait RB, Stoll E, Lane MD (1970). "Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase." Proc Natl Acad Sci U S A 67(3);1353-60. PMID: 4922289

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc13.