|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
L-dopa + S-adenosyl-L-methionine → 3-O-methyldopa + S-adenosyl-L-homocysteine + H+ (188.8.131.52)
3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine → 3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (184.108.40.206)
(R)-adrenaline + S-adenosyl-L-methionine → metanephrine + S-adenosyl-L-homocysteine + H+ (220.127.116.11)
3,4-dihydroxymandelate + S-adenosyl-L-methionine → vanillyl mandelate + S-adenosyl-L-homocysteine + H+ (18.104.22.168)
(R)-noradrenaline + S-adenosyl-L-methionine → normetanephrine + S-adenosyl-L-homocysteine + H+ (22.214.171.124)
S-adenosyl-L-methionine + dopamine → S-adenosyl-L-homocysteine + 3-methoxytyramine + H+ (126.96.36.199)
3,4-dihydroxyphenylacetate + S-adenosyl-L-methionine → homovanillate + S-adenosyl-L-homocysteine + H+ (188.8.131.52)
Enzyme Commission Primary Name: catechol O-methyltransferase
Enzyme Commission Synonyms: COMT I , COMT II, S-COMT (soluble form of catechol-O-methyltransferase), MB-COMT (membrane-bound form of catechol-O-methyltransferase), catechol methyltransferase, catecholamine O-methyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -24.902267 [Latendresse13]
Enzyme Commission Summary:
The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.
Unification Links: KEGG:R07330
Relationship Links: BRENDA:EC:184.108.40.206, ENZYME:EC:220.127.116.11, IUBMB-ExplorEnz:EC:18.104.22.168, UniProt:RELATED-TO:P21964, UniProt:RELATED-TO:P22734, UniProt:RELATED-TO:P46484, UniProt:RELATED-TO:Q04065, UniProt:RELATED-TO:Q06509, UniProt:RELATED-TO:Q42949, UniProt:RELATED-TO:Q42958, UniProt:RELATED-TO:Q43771, UniProt:RELATED-TO:Q96565
Huh79: Huh MM, Friedhoff AJ (1979). "Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization." J Biol Chem 254(2);299-308. PMID: 762061
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