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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: cellulose synthaseInferred from experiment: CesA1
cellulose synthaseInferred from experiment: CesA3
cellulose synthaseInferred from experiment: CesA6
cellulose synthaseInferred from experiment: CesA4
cellulose synthaseInferred from experiment: CesA7
cellulose synthaseInferred from experiment: CesA8
Escherichia coli K-12 substr. MG1655: cellulose synthaseInferred from experiment: bcsB, bcsA

In Pathway: cellulose biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Direct generic reaction:
UDP-α-D-glucose + a 1,4-β-D-glucan → a 1,4-β-D-glucan + UDP (

Enzyme Commission Primary Name: cellulose synthase (UDP-forming)

Enzyme Commission Synonyms: UDP-glucose-β-glucan glucosyltransferase, UDP-glucose-cellulose glucosyltransferase, GS-I, β-1,4-glucosyltransferase, uridine diphosphoglucose-1,4-β-glucan glucosyltransferase, β-1,4-glucan synthase, β-1,4-glucan synthetase, β-glucan synthase, 1,4-β-D-glucan synthase, 1,4-β-glucan synthase, glucan synthase, UDP-glucose-1,4-β-glucan glucosyltransferase, uridine diphosphoglucose-cellulose glucosyltransferase, UDP-glucose:1,4-β-D-glucan 4-β-D-glucosyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 62.237427Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [ EC cellulose synthase (GDP-forming)].

Citations: [GLASER58]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02889

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:Q59167


GLASER58: GLASER L (1958). "The synthesis of cellulose in cell-free extracts of Acetobacter xylinum." J Biol Chem 232(2);627-36. PMID: 13549448

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc11.