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MetaCyc Reaction: 2.4.1.12

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.4.1.12

Enzymes and Genes:

Arabidopsis thaliana col : cellulose synthase Inferred from experiment : CesA1
cellulose synthase Inferred from experiment : CesA3
cellulose synthase Inferred from experiment : CesA6
cellulose synthase Inferred from experiment : CesA4
cellulose synthase Inferred from experiment : CesA7
cellulose synthase Inferred from experiment : CesA8
Escherichia coli K-12 substr. MG1655 : cellulose synthase Inferred from experiment : bcsB , bcsA

In Pathway: cellulose biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Direct generic reaction:
UDP-α-D-glucose + a 1,4-β-D-glucan → a 1,4-β-D-glucan + UDP (2.4.1.168)

Enzyme Commission Primary Name: cellulose synthase (UDP-forming)

Enzyme Commission Synonyms: UDP-glucose-β-glucan glucosyltransferase, UDP-glucose-cellulose glucosyltransferase, GS-I, β-1,4-glucosyltransferase, uridine diphosphoglucose-1,4-β-glucan glucosyltransferase, β-1,4-glucan synthase, β-1,4-glucan synθse, β-glucan synthase, 1,4-β-D-glucan synthase, 1,4-β-glucan synthase, glucan synthase, UDP-glucose-1,4-β-glucan glucosyltransferase, uridine diphosphoglucose-cellulose glucosyltransferase, UDP-glucose:1,4-β-D-glucan 4-β-D-glucosyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 62.237427 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [EC 2.4.1.29 cellulose synthase (GDP-forming)].

Citations: [GLASER58]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02889

Relationship Links: BRENDA:EC:2.4.1.12 , ENZYME:EC:2.4.1.12 , IUBMB-ExplorEnz:EC:2.4.1.12 , UniProt:RELATED-TO:Q59167


References

GLASER58: GLASER L (1958). "The synthesis of cellulose in cell-free extracts of Acetobacter xylinum." J Biol Chem 232(2);627-36. PMID: 13549448

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon May 4, 2015, biocyc12.