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MetaCyc Reaction: 3.5.1.23

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.1.23

Enzymes and Genes:

Mus musculus : N-acylsphingosine amidohydrolase 2 Inferred from experiment : Asah2
N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 Inferred from experiment : Asah3
N-acylsphingosine amidohydrolase 1 Inferred from experiment : Asah1

In Pathway: sphingosine and sphingosine-1-phosphate metabolism

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ceramidase

Enzyme Commission Synonyms: acylsphingosine deacylase, glycosphingolipid ceramide deacylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 368.67322 Inferred by computational analysis [Latendresse13]

Citations: [Nilsson69, Yavin69]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01493 , Rhea:20856

Relationship Links: BRENDA:EC:3.5.1.23 , ENZYME:EC:3.5.1.23 , IUBMB-ExplorEnz:EC:3.5.1.23


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nilsson69: Nilsson A (1969). "The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract." Biochim Biophys Acta 176(2);339-47. PMID: 5775951

Yavin69: Yavin E, Gatt S (1969). "Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase." Biochemistry 8(4);1692-8. PMID: 5805303


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Aug 27, 2015, biocyc13.